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CENPN centromere protein N [ Homo sapiens (human) ]

Gene ID: 55839, updated on 7-Jun-2020

Summary

Official Symbol
CENPNprovided by HGNC
Official Full Name
centromere protein Nprovided by HGNC
Primary source
HGNC:HGNC:30873
See related
Ensembl:ENSG00000166451 MIM:611509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM039; CENP-N; ICEN32; C16orf60
Summary
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in prostate (RPKM 4.4), bone marrow (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See CENPN in Genome Data Viewer
Location:
16q23.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (81006498..81033107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (81040103..81066712)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromodomain Y like 2 Neighboring gene androgen receptor regulated long noncoding RNA 1 Neighboring gene C-X9-C motif containing 2 Neighboring gene CENPN antisense RNA 1 Neighboring gene uncharacterized LOC105371361 Neighboring gene chromosome 16 open reading frame 46 Neighboring gene ATM interactor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13607, FLJ22660

Gene Ontology Provided by GOA

Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
kinetochore assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
centromere protein N
Names
interphase centromere complex protein 32

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100624.2NP_001094094.2  centromere protein N isoform 2

    See identical proteins and their annotated locations for NP_001094094.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092718, AK023669, BC007334, BC039021, HY167728
    Consensus CDS
    CCDS42200.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000305608.5, ENST00000305850.9
    Conserved Domains (1) summary
    pfam05238
    Location:3339
    CENP-N; Kinetochore protein CHL4 like
  2. NM_001100625.2NP_001094095.2  centromere protein N isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092718, AK023669, AK026313, BC007334, HY374758
    Consensus CDS
    CCDS42199.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000377007.3, ENST00000393335.7
    Conserved Domains (1) summary
    pfam05238
    Location:3315
    CENP-N; Kinetochore protein CHL4 like
  3. NM_001270473.1NP_001257402.1  centromere protein N isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AC092718, AK023669, AK296024, BC007334, BC039021
    Consensus CDS
    CCDS58483.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000395235.3, ENST00000439957.7
    Conserved Domains (1) summary
    pfam05238
    Location:3319
    CENP-N; Kinetochore protein CHL4 like
  4. NM_001270474.1NP_001257403.1  centromere protein N isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the coding region and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AC092718, AK023669, AK298554, BC007334, BC039021, HY363272
    Consensus CDS
    CCDS58482.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000393991.2, ENST00000428963.6
    Conserved Domains (1) summary
    pfam05238
    Location:3305
    CENP-N; Kinetochore protein CHL4 like
  5. NM_018455.5NP_060925.2  centromere protein N isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons in the 3' coding region and uses an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092718, AK023669, BC007334, BQ013821, HY167728
    Consensus CDS
    CCDS10931.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000299572.5, ENST00000299572.9
    Conserved Domains (1) summary
    pfam05238
    Location:3165
    CENP-N; Kinetochore protein CHL4 like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    81006498..81033107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721236.4XP_006721299.1  centromere protein N isoform X1

    See identical proteins and their annotated locations for XP_006721299.1

    UniProtKB/Swiss-Prot
    Q96H22
    Conserved Domains (1) summary
    pfam05238
    Location:3339
    CENP-N; Kinetochore protein CHL4 like
  2. XM_017023456.2XP_016878945.1  centromere protein N isoform X2

    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000454327.1, ENST00000564669.5
    Conserved Domains (1) summary
    pfam05238
    Location:3165
    CENP-N; Kinetochore protein CHL4 like
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