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CENPN centromere protein N [ Homo sapiens (human) ]

Gene ID: 55839, updated on 17-Jun-2019

Summary

Official Symbol
CENPNprovided by HGNC
Official Full Name
centromere protein Nprovided by HGNC
Primary source
HGNC:HGNC:30873
See related
Ensembl:ENSG00000166451 MIM:611509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM039; CENP-N; ICEN32; C16orf60
Summary
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in prostate (RPKM 4.4), bone marrow (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See CENPN in Genome Data Viewer
Location:
16q23.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (81006498..81033107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (81040103..81066712)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromodomain Y like 2 Neighboring gene androgen receptor regulated long noncoding RNA 1 Neighboring gene C-X9-C motif containing 2 Neighboring gene uncharacterized LOC107984858 Neighboring gene uncharacterized LOC105371361 Neighboring gene chromosome 16 open reading frame 46 Neighboring gene ATM interactor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
    Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
  • Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystem (from REACTOME)
    Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystemEukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophas...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Nucleosome assembly, organism-specific biosystem (from REACTOME)
    Nucleosome assembly, organism-specific biosystemThe formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13607, FLJ22660

Gene Ontology Provided by GOA

Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
kinetochore assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
centromere protein N
Names
interphase centromere complex protein 32

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100624.2NP_001094094.2  centromere protein N isoform 2

    See identical proteins and their annotated locations for NP_001094094.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092718, AK023669, BC007334, BC039021, HY167728
    Consensus CDS
    CCDS42200.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000305608.5, ENST00000305850.9
    Conserved Domains (1) summary
    pfam05238
    Location:3339
    CENP-N; Kinetochore protein CHL4 like
  2. NM_001100625.2NP_001094095.2  centromere protein N isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092718, AK023669, AK026313, BC007334, HY374758
    Consensus CDS
    CCDS42199.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000377007.3, ENST00000393335.7
    Conserved Domains (1) summary
    pfam05238
    Location:3315
    CENP-N; Kinetochore protein CHL4 like
  3. NM_001270473.1NP_001257402.1  centromere protein N isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AC092718, AK023669, AK296024, BC007334, BC039021
    Consensus CDS
    CCDS58483.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000395235.3, ENST00000439957.7
    Conserved Domains (1) summary
    pfam05238
    Location:3319
    CENP-N; Kinetochore protein CHL4 like
  4. NM_001270474.1NP_001257403.1  centromere protein N isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the coding region and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AC092718, AK023669, AK298554, BC007334, BC039021, HY363272
    Consensus CDS
    CCDS58482.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000393991.2, ENST00000428963.6
    Conserved Domains (1) summary
    pfam05238
    Location:3305
    CENP-N; Kinetochore protein CHL4 like
  5. NM_018455.5NP_060925.2  centromere protein N isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons in the 3' coding region and uses an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092718, AK023669, BC007334, BQ013821, HY167728
    Consensus CDS
    CCDS10931.1
    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000299572.5, ENST00000299572.9
    Conserved Domains (1) summary
    pfam05238
    Location:3165
    CENP-N; Kinetochore protein CHL4 like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    81006498..81033107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721236.4XP_006721299.1  centromere protein N isoform X1

    See identical proteins and their annotated locations for XP_006721299.1

    UniProtKB/Swiss-Prot
    Q96H22
    Conserved Domains (1) summary
    pfam05238
    Location:3339
    CENP-N; Kinetochore protein CHL4 like
  2. XM_017023456.2XP_016878945.1  centromere protein N isoform X2

    UniProtKB/Swiss-Prot
    Q96H22
    Related
    ENSP00000454327.1, ENST00000564669.5
    Conserved Domains (1) summary
    pfam05238
    Location:3165
    CENP-N; Kinetochore protein CHL4 like
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