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UBAP2 ubiquitin associated protein 2 [ Homo sapiens (human) ]

Gene ID: 55833, updated on 24-Nov-2020

Summary

Official Symbol
UBAP2provided by HGNC
Official Full Name
ubiquitin associated protein 2provided by HGNC
Primary source
HGNC:HGNC:14185
See related
Ensembl:ENSG00000137073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBAP-2
Summary
The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 18.9), adrenal (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See UBAP2 in Genome Data Viewer
Location:
9p13.3
Exon count:
32
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (33921693..34049199, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33921691..34048947, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene serine protease 3 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene ubiquitin conjugating enzyme E2 R2 Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene small nucleolar RNA, C/D box 121A Neighboring gene oligosaccharyltransferase complex subunit pseudogene 8 Neighboring gene RNA, U7 small nuclear 36 pseudogene Neighboring gene RN7SK pseudogene 114 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene TUBB4B pseudogene 2 Neighboring gene tubulin beta pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated ubiquitin associated protein 2 (UBAP2) is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22435, FLJ43947, FLJ46567, KIAA1491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
P-body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-associated protein 2
Names
AD-012 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282530.2NP_001269459.1  ubiquitin-associated protein 2 isoform 5

    See identical proteins and their annotated locations for NP_001269459.1

    Status: REVIEWED

    Source sequence(s)
    AL139113
    Consensus CDS
    CCDS75828.1
    UniProtKB/Swiss-Prot
    Q5T6F2
    UniProtKB/TrEMBL
    Q9P0H6
    Related
    ENSP00000368541.5, ENST00000379239.8
  2. NM_001370059.2NP_001356988.2  ubiquitin-associated protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
    Conserved Domains (2) summary
    cd14277
    Location:5390
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512541
    DUF3697; Ubiquitin-associated protein 2
  3. NM_001370062.2NP_001356991.2  ubiquitin-associated protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
    Related
    ENSP00000368540.1, ENST00000379238.6
    Conserved Domains (2) summary
    cd14277
    Location:5390
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512541
    DUF3697; Ubiquitin-associated protein 2
  4. NM_001370064.2NP_001356993.2  ubiquitin-associated protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
  5. NM_001370066.2NP_001356995.2  ubiquitin-associated protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
  6. NM_001370067.2NP_001356996.2  ubiquitin-associated protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
  7. NM_001370068.2NP_001356997.2  ubiquitin-associated protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
  8. NM_018449.3NP_060919.3  ubiquitin-associated protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB040924, AF157327, AK294952, AK302335, BG723831
    Consensus CDS
    CCDS6547.1
    UniProtKB/Swiss-Prot
    Q5T6F2
    UniProtKB/TrEMBL
    B4DH66, B7Z7P2, Q9P0H6
    Related
    ENSP00000354039.1, ENST00000360802.5
    Conserved Domains (2) summary
    cd14277
    Location:5390
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512541
    DUF3697; Ubiquitin-associated protein 2

RNA

  1. NR_163243.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL139113, AL354989
    Related
    ENST00000629575.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    33921693..34049199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001282529.1: Suppressed sequence

    Description
    NM_001282529.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_020867.1: Suppressed sequence

    Description
    NM_020867.1: This RefSeq was permanently suppressed because insufficient evidence was found to support the expression of this transcript.
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