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GLT8D1 glycosyltransferase 8 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55830, updated on 3-Jun-2018
Official Symbol
GLT8D1provided by HGNC
Official Full Name
glycosyltransferase 8 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:24870
See related
Ensembl:ENSG00000016864 Vega:OTTHUMG00000158759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD-017; MSTP139
Summary
This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in thyroid (RPKM 29.7), testis (RPKM 28.8) and 25 other tissues See more
Orthologs
See GLT8D1 in Genome Data Viewer
Location:
3p21.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (52694484..52706083, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52728500..52740099, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene G protein nucleolar 3 Neighboring gene small nucleolar RNA, C/D box 19C Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene signal peptidase complex subunit 1 Neighboring gene NIMA related kinase 4 Neighboring gene zinc finger protein 610 pseudogene Neighboring gene adenylate kinase 3 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Addition of peripheral sugar residues such as galactose, N-acetylglucosamine, and sialic acid to HIV-1 gp120 is processed by specific glycosyltransferase PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14611, DKFZp781O20198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transferase activity, transferring glycosyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
Preferred Names
glycosyltransferase 8 domain-containing protein 1
Names
glycosyltransferase AD-017
NP_001010983.1
NP_001265209.1
NP_001265210.1
NP_060916.1
NP_690909.1
XP_024309409.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010983.2NP_001010983.1  glycosyltransferase 8 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001010983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AF157318, AF175227, AJ271710, BI495741, BI559798
    Consensus CDS
    CCDS2862.1
    UniProtKB/Swiss-Prot
    Q68CQ7
    UniProtKB/TrEMBL
    A0A024R313
    Conserved Domains (1) summary
    cd06429
    Location:66351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function
  2. NM_001278280.1NP_001265209.1  glycosyltransferase 8 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001265209.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AF157318, AF176777, AK027517, BC119671, BI495741, BI559798
    Consensus CDS
    CCDS2862.1
    UniProtKB/Swiss-Prot
    Q68CQ7
    UniProtKB/TrEMBL
    A0A024R313, Q7Z4D0
    Conserved Domains (1) summary
    cd06429
    Location:66351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function
  3. NM_001278281.1NP_001265210.1  glycosyltransferase 8 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001265210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AK027517, BI495741, BI559798, CR749821
    Consensus CDS
    CCDS2862.1
    UniProtKB/Swiss-Prot
    Q68CQ7
    UniProtKB/TrEMBL
    A0A024R313
    Related
    ENSP00000419612.2, OTTHUMP00000213401, ENST00000478968.6, OTTHUMT00000352065
    Conserved Domains (1) summary
    cd06429
    Location:66351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function
  4. NM_018446.3NP_060916.1  glycosyltransferase 8 domain-containing protein 1

    See identical proteins and their annotated locations for NP_060916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AF157318, BI495741, BI559798
    Consensus CDS
    CCDS2862.1
    UniProtKB/Swiss-Prot
    Q68CQ7
    UniProtKB/TrEMBL
    A0A024R313
    Related
    ENSP00000266014.5, ENST00000266014.10
    Conserved Domains (1) summary
    cd06429
    Location:66351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function
  5. NM_152932.2NP_690909.1  glycosyltransferase 8 domain-containing protein 1

    See identical proteins and their annotated locations for NP_690909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AK027517, AK311674, BC119670, BI495741
    Consensus CDS
    CCDS2862.1
    UniProtKB/Swiss-Prot
    Q68CQ7
    UniProtKB/TrEMBL
    A0A024R313
    Related
    ENSP00000378263.3, OTTHUMP00000213440, ENST00000394783.7, OTTHUMT00000352144
    Conserved Domains (1) summary
    cd06429
    Location:66351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    52694484..52706083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453641.1XP_024309409.1  glycosyltransferase 8 domain-containing protein 1 isoform X1

    Related
    ENSP00000417713.1, ENST00000479553.5
    Conserved Domains (1) summary
    cl11394
    Location:66178
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_002959551.1 RNA Sequence

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