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PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 [ Homo sapiens (human) ]

Gene ID: 55824, updated on 5-Jan-2022

Summary

Official Symbol
PAG1provided by HGNC
Official Full Name
phosphoprotein membrane anchor with glycosphingolipid microdomains 1provided by HGNC
Primary source
HGNC:HGNC:30043
See related
Ensembl:ENSG00000076641 MIM:605767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBP; PAG
Summary
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 8.7), placenta (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

See PAG1 in Genome Data Viewer
Location:
8q21.13
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (80967810..81112068, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81880045..82024303, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986894 Neighboring gene HNF4 motif-containing MPRA enhancer 108 Neighboring gene uncharacterized LOC105375924 Neighboring gene ubiquitin conjugating enzyme E2 H pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37858, MGC138364

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Names
Csk-binding protein
phosphoprotein associated with glycosphingolipid microdomains 1
transmembrane adapter protein PAG
transmembrane adaptor protein PAG
transmembrane phosphoprotein Cbp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018440.4NP_060910.3  phosphoprotein associated with glycosphingolipid-enriched microdomains 1

    See identical proteins and their annotated locations for NP_060910.3

    Status: REVIEWED

    Source sequence(s)
    AA766638, AC012533, AK000680, BC090931, BX426120, CB960651
    Consensus CDS
    CCDS6227.1
    UniProtKB/Swiss-Prot
    Q9NWQ8
    Related
    ENSP00000220597.3, ENST00000220597.4
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    80967810..81112068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013642.2XP_016869131.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched
  2. XM_017013641.1XP_016869130.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched
  3. XM_017013643.1XP_016869132.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched
  4. XM_017013640.2XP_016869129.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

RNA

  1. XR_928792.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007549.1: Suppressed sequence

    Description
    NM_001007549.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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