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PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 [ Homo sapiens (human) ]

Gene ID: 55824, updated on 18-Nov-2018

Summary

Official Symbol
PAG1provided by HGNC
Official Full Name
phosphoprotein membrane anchor with glycosphingolipid microdomains 1provided by HGNC
Primary source
HGNC:HGNC:30043
See related
Ensembl:ENSG00000076641 MIM:605767; Vega:OTTHUMG00000164592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBP; PAG
Summary
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 8.7), placenta (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See PAG1 in Genome Data Viewer
Location:
8q21.13
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (80967810..81112068, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81880045..82024303, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986894 Neighboring gene HNF4 motif-containing MPRA enhancer 108 Neighboring gene uncharacterized LOC105375924 Neighboring gene ubiquitin conjugating enzyme E2 H pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    BCR signaling pathway, organism-specific biosystem
    BCR signaling pathway
  • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR4-mediated signaling events, organism-specific biosystem
    CXCR4-mediated signaling events
  • GAB1 signalosome, organism-specific biosystem (from REACTOME)
    GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
    Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells
  • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD8+ T cells, organism-specific biosystem
    TCR signaling in naive CD8+ T cells

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37858, MGC138364

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
SH3/SH2 adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Names
Csk-binding protein
phosphoprotein associated with glycosphingolipid microdomains 1
transmembrane adapter protein PAG
transmembrane adaptor protein PAG
transmembrane phosphoprotein Cbp

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018440.3NP_060910.3  phosphoprotein associated with glycosphingolipid-enriched microdomains 1

    See identical proteins and their annotated locations for NP_060910.3

    Status: REVIEWED

    Source sequence(s)
    AA766638, AC012533, AK000680, BC090931, BX426120, CB960651
    Consensus CDS
    CCDS6227.1
    UniProtKB/Swiss-Prot
    Q9NWQ8
    Related
    ENSP00000220597.3, OTTHUMP00000227022, ENST00000220597.4, OTTHUMT00000379352
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    80967810..81112068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013642.2XP_016869131.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched
  2. XM_017013641.1XP_016869130.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched
  3. XM_017013643.1XP_016869132.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched
  4. XM_017013640.2XP_016869129.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NWQ8
    Conserved Domains (1) summary
    pfam15347
    Location:2432
    PAG; Phosphoprotein associated with glycosphingolipid-enriched

RNA

  1. XR_928792.3 RNA Sequence

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