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PRKCG protein kinase C gamma [ Homo sapiens (human) ]

Gene ID: 5582, updated on 5-Jul-2025
Official Symbol
PRKCGprovided by HGNC
Official Full Name
protein kinase C gammaprovided by HGNC
Primary source
HGNC:HGNC:9402
See related
Ensembl:ENSG00000126583 MIM:176980; AllianceGenome:HGNC:9402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Biased expression in brain (RPKM 15.6) and testis (RPKM 1.4) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See PRKCG in Genome Data Viewer
Location:
19q13.42
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53881094..53907652)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56960799..56987358)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54385451..54410906)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54300296-54300796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54301378-54301878 Neighboring gene NLR family pyrin domain containing 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54332809-54333578 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54334349-54335116 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54335887-54336656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54337427-54338194 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54339735-54340504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54342811-54343580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54343581-54344348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54361270-54361770 Neighboring gene MYADM antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54369942-54370917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372027-54372940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372941-54373854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54385903-54386454 Neighboring gene myeloid associated differentiation marker Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54395841-54396380 Neighboring gene Sharpr-MPRA regulatory region 4174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54410617-54411158 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene MPRA-validated peak3551 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54460576-54461110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54463321-54464221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54465032-54465552 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54483237-54483769 Neighboring gene microRNA 935

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
Tat tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC57564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chemosensory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in innervation IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mismatch repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of response to food IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of response to food ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to angiotensin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to morphine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to morphine ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
 
involved_in response to pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to psychosocial stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic signaling via neuropeptide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synaptic signaling via neuropeptide ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in calyx of Held IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein kinase C gamma type
NP_001303258.1
NP_002730.1
XP_047295048.1
XP_054177413.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009114.1 RefSeqGene

    Range
    5001..30435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_669

mRNA and Protein(s)

  1. NM_001316329.2NP_001303258.1  protein kinase C gamma type isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC008440, AK296434, AK312302, BC047876, DC318717
    Consensus CDS
    CCDS92683.1
    UniProtKB/TrEMBL
    A0A804HIU5, B7Z3W6
    Related
    ENSP00000507230.1, ENST00000682028.1
    Conserved Domains (4) summary
    cd04026
    Location:158289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:351614
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:354677
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:101153
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. NM_002739.5NP_002730.1  protein kinase C gamma type isoform 2

    See identical proteins and their annotated locations for NP_002730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008440, BC047876, DC318717
    Consensus CDS
    CCDS12867.1
    UniProtKB/Swiss-Prot
    B7Z8Q0, P05129
    UniProtKB/TrEMBL
    B2R5T1
    Related
    ENSP00000263431.3, ENST00000263431.4
    Conserved Domains (4) summary
    cd04026
    Location:158289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:351614
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:354677
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:101153
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53881094..53907652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439092.1XP_047295048.1  protein kinase C gamma type isoform X1

    UniProtKB/TrEMBL
    B7Z3V9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56960799..56987358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321438.1XP_054177413.1  protein kinase C gamma type isoform X1

    UniProtKB/TrEMBL
    B7Z3V9