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TSNAXIP1 translin associated factor X interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 55815, updated on 5-Aug-2022

Summary

Official Symbol
TSNAXIP1provided by HGNC
Official Full Name
translin associated factor X interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:18586
See related
Ensembl:ENSG00000102904 MIM:607720; AllianceGenome:HGNC:18586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TXI1
Summary
Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 14.4), brain (RPKM 1.0) and 3 other tissues See more
Orthologs
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Genomic context

See TSNAXIP1 in Genome Data Viewer
Location:
16q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67806889..67828068)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73601912..73623850)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67840792..67861971)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene RAN binding protein 10 Neighboring gene Sharpr-MPRA regulatory region 12647 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111443

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
translin-associated factor X-interacting protein 1
Names
trax-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054717.1 RefSeqGene

    Range
    5317..26496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288990.3NP_001275919.1  translin-associated factor X-interacting protein 1 isoform a

    See identical proteins and their annotated locations for NP_001275919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK301920, BC062628, BU607826
    Consensus CDS
    CCDS73903.1
    UniProtKB/TrEMBL
    B4DXD0
    Related
    ENSP00000457241.1, ENST00000561639.6
    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  2. NM_001288991.3NP_001275920.1  translin-associated factor X-interacting protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AK303841, BC062628, BC111018, BU607826
    Consensus CDS
    CCDS73904.1
    UniProtKB/TrEMBL
    E7ENJ7
    Related
    ENSP00000411472.3, ENST00000415766.7
    Conserved Domains (1) summary
    pfam15739
    Location:92142
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  3. NM_001288992.3NP_001275921.1  translin-associated factor X-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001275921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    BC062628, BU607826
    UniProtKB/Swiss-Prot
    Q2TAA8
    UniProtKB/TrEMBL
    A0A024R6Y0
  4. NM_001288993.3NP_001275922.1  translin-associated factor X-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001275922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AF132730, BC062628, BU607826
    UniProtKB/Swiss-Prot
    Q2TAA8
    UniProtKB/TrEMBL
    A0A024R6Y0
    Related
    ENST00000487120.5
  5. NM_001288994.3NP_001275923.1  translin-associated factor X-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001275923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    BC050693, BC062628, BU607826
    UniProtKB/Swiss-Prot
    Q2TAA8
    UniProtKB/TrEMBL
    A0A024R6Y0
    Related
    ENST00000565339.5
  6. NM_001351158.2NP_001338087.1  translin-associated factor X-interacting protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, initiates translation at an alternate start codon, lacks three exons, and uses an alternate in-frame splice site in its 5' coding region compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC040162, BU607826
    Conserved Domains (1) summary
    pfam15739
    Location:73123
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  7. NM_018430.4NP_060900.2  translin-associated factor X-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_060900.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    BC062628, BC111018, BU607634
    Consensus CDS
    CCDS10846.2
    UniProtKB/Swiss-Prot
    Q2TAA8, Q9P105
    Related
    ENSP00000373485.3, ENST00000388833.7
    Conserved Domains (2) summary
    pfam15739
    Location:54157
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
    cl25732
    Location:48316
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67806889..67828068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523230.3XP_011521532.1  translin-associated factor X-interacting protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  2. XM_011523232.3XP_011521534.1  translin-associated factor X-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  3. XM_011523233.3XP_011521535.1  translin-associated factor X-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  4. XM_011523231.3XP_011521533.1  translin-associated factor X-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  5. XM_011523234.3XP_011521536.1  translin-associated factor X-interacting protein 1 isoform X5

    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  6. XM_005256049.5XP_005256106.1  translin-associated factor X-interacting protein 1 isoform X6

    Conserved Domains (1) summary
    pfam15739
    Location:108211
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  7. XM_011523239.2XP_011521541.1  translin-associated factor X-interacting protein 1 isoform X12

  8. XM_024450351.2XP_024306119.1  translin-associated factor X-interacting protein 1 isoform X16

  9. XM_011523236.4XP_011521538.1  translin-associated factor X-interacting protein 1 isoform X7

    Conserved Domains (1) summary
    pfam15739
    Location:92142
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  10. XM_017023445.3XP_016878934.1  translin-associated factor X-interacting protein 1 isoform X8

  11. XM_017023447.3XP_016878936.1  translin-associated factor X-interacting protein 1 isoform X14

  12. XM_017023449.3XP_016878938.1  translin-associated factor X-interacting protein 1 isoform X17

  13. XM_011523237.3XP_011521539.1  translin-associated factor X-interacting protein 1 isoform X9

    Conserved Domains (1) summary
    pfam15739
    Location:44131
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  14. XM_011523238.2XP_011521540.1  translin-associated factor X-interacting protein 1 isoform X10

    Conserved Domains (1) summary
    pfam15739
    Location:73123
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus
  15. XM_024450350.2XP_024306118.1  translin-associated factor X-interacting protein 1 isoform X11

    Conserved Domains (1) summary
    cl25732
    Location:46282
    SMC_N; RecF/RecN/SMC N terminal domain
  16. XM_017023446.2XP_016878935.1  translin-associated factor X-interacting protein 1 isoform X13

  17. XM_017023448.2XP_016878937.1  translin-associated factor X-interacting protein 1 isoform X15

    Conserved Domains (1) summary
    pfam15739
    Location:73123
    TSNAXIP1_N; Translin-associated factor X-interacting N-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73601912..73623850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)