tcf21 transcription factor 21 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcf21provided by ZNC
Official Full Name: transcription factor 21provided by ZNC
Primary source: ZFIN:ZDB-GENE-051113-88
See related: Ensembl:ENSDARG00000036869 AllianceGenome:ZFIN:ZDB-GENE-051113-88
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:123313
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Acts upstream of or within artery development and branchiomeric skeletal muscle development. Located in nucleus. Is expressed in cardiovascular system; head muscle; mesenchymal cell; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	23	NC_133198.1 (34496852..34549768, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (31554269..31555696, complement)

Chromosome 23 - NC_133198.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Capsulin has an essential role in zebrafish craniofacial myogenesis.
Title: Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish.
Upstream sequences of the transcription factor gene tcf21 activate robust, epicardium-specific expression throughout development and regeneration.
Title: tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration.
Endogenous Capsulin was distributed mainly in the epicardial cells of zebrafish.
Title: Biochemical and structural properties of zebrafish Capsulin produced by Escherichia coli.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Sertoli cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within artery development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branchiomeric skeletal muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branchiomeric skeletal muscle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in bronchiole development	ISS Inferred from Sequence or Structural Similarity more info
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diaphragm development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in gland development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerulus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric glomerular capillary formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric mesenchymal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of a branching structure	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive structure development	ISS Inferred from Sequence or Structural Similarity more info
involved_in respiratory system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in roof of mouth development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sex determination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spleen development	ISS Inferred from Sequence or Structural Similarity more info
involved_in striated muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculature development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor 21

Names: TCF-21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037681.3 → NP_001032770.2 transcription factor 21

Status: VALIDATED

Source sequence(s)

JBMGRA010000023

UniProtKB/Swiss-Prot

Q32PV5

UniProtKB/TrEMBL

A0AC58IK48

Related

ENSDARP00000053538.5, ENSDART00000053539.6

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133198.1 Reference GRCz12tu Primary Assembly

Range

34496852..34549768 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073938475.1 → XP_073794576.1 transcription factor 21 isoform X2

UniProtKB/Swiss-Prot

Q32PV5

UniProtKB/TrEMBL

A0AC58IK48
XM_073938474.1 → XP_073794575.1 transcription factor 21 isoform X1

UniProtKB/Swiss-Prot

Q32PV5

UniProtKB/TrEMBL

A0AC58IK07