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BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB [ Homo sapiens (human) ]

Gene ID: 55814, updated on 7-Oct-2018

Summary

Official Symbol
BDP1provided by HGNC
Official Full Name
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBprovided by HGNC
Primary source
HGNC:HGNC:13652
See related
Ensembl:ENSG00000145734 MIM:607012; Vega:OTTHUMG00000162506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFC5; TFNR; TAF3B1; TFIIIB''; TFIIIB90; HSA238520; TFIIIB150
Summary
The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 5.4), lymph node (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See BDP1 in Genome Data Viewer
Location:
5q13.2
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (71455615..71578288)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (70751442..70863649)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986421 Neighboring gene uncharacterized LOC105379026 Neighboring gene long intergenic non-protein coding RNA 2197 Neighboring gene uncharacterized LOC105379025 Neighboring gene pro-melanin concentrating hormone like 2 (pseudogene) Neighboring gene sterol carrier protein 2 pseudogene Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 12 Neighboring gene methylcrotonoyl-CoA carboxylase 2 Neighboring gene CART prepropeptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1241, KIAA1689, DKFZp686K0831, DKFZp686C01233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
TFIIIC-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase III preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor TFIIIB component B'' homolog
Names
RNA polymerase III transcription initiation factor B''
TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1
transcription factor IIIB 150
transcription factor-like nuclear regulator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047017.1 RefSeqGene

    Range
    5233..117440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018429.2NP_060899.2  transcription factor TFIIIB component B'' homolog

    See identical proteins and their annotated locations for NP_060899.2

    Status: REVIEWED

    Source sequence(s)
    AB051476, AC138832, AI537645, BP246483, BP347992
    Consensus CDS
    CCDS43328.1
    UniProtKB/Swiss-Prot
    A6H8Y1
    Related
    ENSP00000351575.4, OTTHUMP00000224505, ENST00000358731.8, OTTHUMT00000374681
    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    71455615..71578288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009630.1XP_016865119.1  transcription factor TFIIIB component B'' homolog isoform X1

  2. XM_017009631.1XP_016865120.1  transcription factor TFIIIB component B'' homolog isoform X1

  3. XM_011543511.3XP_011541813.1  transcription factor TFIIIB component B'' homolog isoform X2

    See identical proteins and their annotated locations for XP_011541813.1

    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like
  4. XM_011543512.2XP_011541814.1  transcription factor TFIIIB component B'' homolog isoform X4

    See identical proteins and their annotated locations for XP_011541814.1

    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like
  5. XM_017009632.1XP_016865121.1  transcription factor TFIIIB component B'' homolog isoform X3

    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like
  6. XM_017009633.1XP_016865122.1  transcription factor TFIIIB component B'' homolog isoform X5

  7. XM_017009634.1XP_016865123.1  transcription factor TFIIIB component B'' homolog isoform X6

    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315917.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1454100..1566307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_187651.1 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    985599..1097797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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