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BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB [ Homo sapiens (human) ]

Gene ID: 55814, updated on 12-Aug-2022

Summary

Official Symbol
BDP1provided by HGNC
Official Full Name
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBprovided by HGNC
Primary source
HGNC:HGNC:13652
See related
Ensembl:ENSG00000145734 MIM:607012; AllianceGenome:HGNC:13652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFC5; TFNR; TAF3B1; DFNB112; TFIIIB''; TFIIIB90; HSA238520; TFIIIB150
Summary
The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 5.4), lymph node (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See BDP1 in Genome Data Viewer
Location:
5q13.2
Exon count:
41
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (71455651..71578288)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (71936967..72049156)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (70751478..70863647)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2197 Neighboring gene uncharacterized LOC105379025 Neighboring gene pro-melanin concentrating hormone like 2 (pseudogene) Neighboring gene uncharacterized LOC107987420 Neighboring gene sterol carrier protein 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10712 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 12 Neighboring gene uncharacterized LOC124900999 Neighboring gene methylcrotonyl-CoA carboxylase subunit 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hearing loss, autosomal recessive 112
MedGen: C4748855 OMIM: 618257 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1241, KIAA1689, DKFZp686K0831, DKFZp686C01233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables TFIIIC-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase III preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor TFIIIB component B'' homolog
Names
RNA polymerase III transcription initiation factor B''
TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1
transcription factor IIIB 150
transcription factor-like nuclear regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047017.1 RefSeqGene

    Range
    5269..117438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018429.3NP_060899.2  transcription factor TFIIIB component B'' homolog

    See identical proteins and their annotated locations for NP_060899.2

    Status: REVIEWED

    Source sequence(s)
    AB051476, AC138832, AI537645, BP246483, BP347992
    Consensus CDS
    CCDS43328.1
    UniProtKB/Swiss-Prot
    A6H8Y1, Q9ULH9
    Related
    ENSP00000351575.4, ENST00000358731.9
    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    71455651..71578288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009630.2XP_016865119.1  transcription factor TFIIIB component B'' homolog isoform X1

  2. XM_047417372.1XP_047273328.1  transcription factor TFIIIB component B'' homolog isoform X1

  3. XM_017009631.2XP_016865120.1  transcription factor TFIIIB component B'' homolog isoform X1

  4. XM_047417373.1XP_047273329.1  transcription factor TFIIIB component B'' homolog isoform X3

  5. XM_011543511.4XP_011541813.1  transcription factor TFIIIB component B'' homolog isoform X2

    See identical proteins and their annotated locations for XP_011541813.1

    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like
  6. XM_011543512.3XP_011541814.1  transcription factor TFIIIB component B'' homolog isoform X4

    See identical proteins and their annotated locations for XP_011541814.1

    Conserved Domains (1) summary
    pfam15963
    Location:297380
    Myb_DNA-bind_7; Myb DNA-binding like
  7. XM_047417374.1XP_047273330.1  transcription factor TFIIIB component B'' homolog isoform X5

    Related
    ENST00000508917.6
  8. XM_047417375.1XP_047273331.1  transcription factor TFIIIB component B'' homolog isoform X6

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791777.1 Reference GRCh38.p14 PATCHES

    Range
    1942759..2065430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443308.1XP_047299264.1  transcription factor TFIIIB component B'' homolog isoform X8

  2. XM_047443310.1XP_047299266.1  transcription factor TFIIIB component B'' homolog isoform X8

  3. XM_047443309.1XP_047299265.1  transcription factor TFIIIB component B'' homolog isoform X8

  4. XM_047443312.1XP_047299268.1  transcription factor TFIIIB component B'' homolog isoform X10

  5. XM_047443307.1XP_047299263.1  transcription factor TFIIIB component B'' homolog isoform X7

    UniProtKB/TrEMBL
    A0A0G2JNU3
  6. XM_047443311.1XP_047299267.1  transcription factor TFIIIB component B'' homolog isoform X9

  7. XM_047443313.1XP_047299269.1  transcription factor TFIIIB component B'' homolog isoform X11

  8. XM_047443314.1XP_047299270.1  transcription factor TFIIIB component B'' homolog isoform X12

  9. XM_047443315.1XP_047299271.1  transcription factor TFIIIB component B'' homolog isoform X13

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315917.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1454136..1566305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187651.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    985635..1097795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    71936967..72049156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)