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ST6GALNAC1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 55808, updated on 23-Nov-2021

Summary

Official Symbol
ST6GALNAC1provided by HGNC
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:23614
See related
Ensembl:ENSG00000070526 MIM:610138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STYI; SIAT7A; HSY11339; ST6GalNAcI
Summary
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in colon (RPKM 93.3), small intestine (RPKM 34.8) and 7 other tissues See more
Orthologs
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Genomic context

See ST6GALNAC1 in Genome Data Viewer
Location:
17q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76617769..76643758, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74620845..74639839, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 16 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Neighboring gene small nucleolar RNA, C/D box 1A Neighboring gene testis-specific serine/proline-rich protein Neighboring gene prothymosin alpha pseudogene 13 Neighboring gene RNA, U6 small nuclear 227, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein glycosylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Names
GalNAc alpha-2, 6-sialyltransferase I, long form
SIAT7-A
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
ST6 GalNAc alpha-2,6-sialyltransferase 1
ST6GALNAC1, alpha-2,6-sialyltransferase 1
ST6GalNAc I
galNAc alpha-2,6-sialyltransferase I
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A
sialyltransferase 7A
NP_001276036.1
NP_060884.1
XP_011523297.1
XP_011523298.1
XP_016880331.1
XP_016880332.1
XP_016880333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289107.2NP_001276036.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001276036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC063830, DA594489
    Conserved Domains (1) summary
    pfam00777
    Location:171457
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_018414.5NP_060884.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_060884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AY358918, DA594489
    Consensus CDS
    CCDS11748.1
    UniProtKB/Swiss-Prot
    Q9NSC7
    Related
    ENSP00000156626.6, ENST00000156626.12
    Conserved Domains (1) summary
    pfam00777
    Location:303589
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_110309.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY358918, BC022462, DA594489
    Related
    ENST00000359088.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76617769..76643758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024842.1XP_016880331.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:303519
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_011524996.2XP_011523298.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:303519
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_011524995.3XP_011523297.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:303519
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_017024843.1XP_016880332.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X3

  5. XM_017024844.2XP_016880333.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X4

RNA

  1. XR_001752559.2 RNA Sequence

    Related
    ENST00000592042.5
  2. XR_002958047.1 RNA Sequence

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