atf6 activating transcription factor 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atf6provided by ZNC
Official Full Name: activating transcription factor 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-328
See related: Ensembl:ENSDARG00000012656 AllianceGenome:ZFIN:ZDB-GENE-041014-328
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi12h10; wu:fi12h10; si:ch211-199m3.9; si:ch211-260g14.1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endoplasmic reticulum unfolded protein response and response to hypoxia. Predicted to be located in membrane. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; female organism; liver; and male organism. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	20	NC_133195.1 (37080337..37136494, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (33811556..33864696, complement)

Chromosome 20 - NC_133195.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver.
Title: A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver.
Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish.
Title: Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish.
overexpression of active, nuclear Atf6 (nAtf6) in hepatocytes caused Fatty liver disease in the absence of stress
Title: Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish.

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General gene information

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Markers

G47016 (e-PCR)
- UniSTS:107808

fi12h10.x1 (e-PCR)
- UniSTS:204456

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-6 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110519.1 → NP_001103989.1 cyclic AMP-dependent transcription factor ATF-6 alpha

Status: PROVISIONAL

Source sequence(s)

JBMGRA010000020

UniProtKB/TrEMBL

A0A8M1NGJ3, Q5RH85

Related

ENSDARP00000009333.7, ENSDART00000007700.9

Conserved Domains (1) summary

cd14700
Location:295 → 346

bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain