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LRP2BP LRP2 binding protein [ Homo sapiens (human) ]

Gene ID: 55805, updated on 15-Jan-2020

Summary

Official Symbol
LRP2BPprovided by HGNC
Official Full Name
LRP2 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:25434
See related
Ensembl:ENSG00000109771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 1.4), brain (RPKM 1.2) and 24 other tissues See more
Orthologs

Genomic context

See LRP2BP in Genome Data Viewer
Location:
4q35.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (185362862..185397297, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186285032..186318297, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 4 Neighboring gene cilia and flagella associated protein 97 Neighboring gene sorting nexin 25 Neighboring gene uncharacterized LOC107986206 Neighboring gene ankyrin repeat domain 37 Neighboring gene chromosome 4 open reading frame 47 Neighboring gene UFM1 specific peptidase 2 Neighboring gene uncharacterized LOC105377590 Neighboring gene coiled-coil domain containing 110

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44965, DKFZp761O0113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
LRP2-binding protein
Names
megBP
megalin-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377440.1NP_001364369.1  LRP2-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073344, AC106897
  2. NM_001377441.1NP_001364370.1  LRP2-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073344, AC106897
  3. NM_001377442.1NP_001364371.1  LRP2-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073344, AC106897
  4. NM_001377443.1NP_001364372.1  LRP2-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073344, AC106897
  5. NM_018409.3NP_060879.2  LRP2-binding protein isoform 1

    See identical proteins and their annotated locations for NP_060879.2

    Status: VALIDATED

    Source sequence(s)
    AC073344, AL161975, BC150161
    Consensus CDS
    CCDS3840.1
    UniProtKB/Swiss-Prot
    Q9P2M1
    Related
    ENSP00000332681.7, ENST00000328559.11
    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    185362862..185397297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263125.5XP_005263182.1  LRP2-binding protein isoform X4

    Conserved Domains (3) summary
    smart00671
    Location:110144
    SEL1; Sel1-like repeats
    COG0790
    Location:1156
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:1147
    SLR; SLR repeat [structural motif]
  2. XM_006714265.4XP_006714328.1  LRP2-binding protein isoform X4

    Conserved Domains (3) summary
    smart00671
    Location:110144
    SEL1; Sel1-like repeats
    COG0790
    Location:1156
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:1147
    SLR; SLR repeat [structural motif]
  3. XM_024454137.1XP_024309905.1  LRP2-binding protein isoform X5

    Conserved Domains (3) summary
    smart00671
    Location:198232
    SEL1; Sel1-like repeats
    COG0790
    Location:35155
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:5386
    SLR; SLR repeat [structural motif]
  4. XM_011532110.3XP_011530412.1  LRP2-binding protein isoform X3

    Conserved Domains (3) summary
    smart00671
    Location:175209
    SEL1; Sel1-like repeats
    COG0790
    Location:28221
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:76112
    SLR; SLR repeat [structural motif]
  5. XM_017008411.2XP_016863900.1  LRP2-binding protein isoform X2

  6. XM_011532111.3XP_011530413.1  LRP2-binding protein isoform X4

    See identical proteins and their annotated locations for XP_011530413.1

    Conserved Domains (3) summary
    smart00671
    Location:110144
    SEL1; Sel1-like repeats
    COG0790
    Location:1156
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:1147
    SLR; SLR repeat [structural motif]
  7. XM_024454136.1XP_024309904.1  LRP2-binding protein isoform X1

    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]
  8. XM_024454138.1XP_024309906.1  LRP2-binding protein isoform X1

    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]
  9. XM_006714260.4XP_006714323.1  LRP2-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9P2M1
    Related
    ENSP00000426203.1, ENST00000505916.5
    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]
  10. XM_017008410.2XP_016863899.1  LRP2-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9P2M1
    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]
  11. XM_024454135.1XP_024309903.1  LRP2-binding protein isoform X1

    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]
  12. XM_024454134.1XP_024309902.1  LRP2-binding protein isoform X1

    Conserved Domains (2) summary
    COG0790
    Location:61254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:109145
    SLR; SLR repeat [structural motif]
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