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ADAP2 ArfGAP with dual PH domains 2 [ Homo sapiens (human) ]

Gene ID: 55803, updated on 1-Jun-2020

Summary

Official Symbol
ADAP2provided by HGNC
Official Full Name
ArfGAP with dual PH domains 2provided by HGNC
Primary source
HGNC:HGNC:16487
See related
Ensembl:ENSG00000184060 MIM:608635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENTA2; cent-b; HSA272195
Summary
The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]
Expression
Broad expression in spleen (RPKM 10.3), placenta (RPKM 9.9) and 23 other tissues See more
Orthologs

Genomic context

See ADAP2 in Genome Data Viewer
Location:
17q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (30921736..30959398)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29248698..29286340)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATPase family AAA domain containing 5 Neighboring gene RNA, U6 small nuclear 298, pseudogene Neighboring gene transcription elongation factor, mitochondrial Neighboring gene RNA, 7SL, cytoplasmic 138, pseudogene Neighboring gene ring finger protein 135 Neighboring gene divergent-paired related homeobox pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
inositol 1,3,4,5 tetrakisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
inositol lipid-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial envelope ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arf-GAP with dual PH domain-containing protein 2
Names
centaurin beta
centaurin-alpha 2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051975.1 RefSeqGene

    Range
    5001..42458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346712.1NP_001333641.1  arf-GAP with dual PH domain-containing protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138207
    Consensus CDS
    CCDS86588.1
    UniProtKB/TrEMBL
    Q2V6Q1
    Related
    ENSP00000464121.1, ENST00000580525.5
  2. NM_001346714.1NP_001333643.1  arf-GAP with dual PH domain-containing protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138207, AJ238994, AK074196, BC033758
    UniProtKB/Swiss-Prot
    Q9NPF8
    Conserved Domains (3) summary
    cd01251
    Location:255361
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8126
    ArfGap; Putative GTPase activating protein for Arf
  3. NM_001346716.1NP_001333645.1  arf-GAP with dual PH domain-containing protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138207
  4. NM_018404.3NP_060874.1  arf-GAP with dual PH domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_060874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138207, AJ272195, BC033758
    Consensus CDS
    CCDS11261.1
    UniProtKB/Swiss-Prot
    Q9NPF8
    Related
    ENSP00000329468.3, ENST00000330889.8
    Conserved Domains (4) summary
    cd01251
    Location:255362
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:258361
    PH; PH domain
    pfam01412
    Location:8126
    ArfGap; Putative GTPase activating protein for Arf

RNA

  1. NR_144488.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138207
    Related
    ENST00000585130.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    30921736..30959398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450835.1XP_024306603.1  arf-GAP with dual PH domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    cd01251
    Location:133240
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:11119
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
  2. XM_024450834.1XP_024306602.1  arf-GAP with dual PH domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    cd13252
    Location:139247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8132
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:261353
    PH-like; Pleckstrin homology-like domain
  3. XM_024450832.1XP_024306600.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    cd01251
    Location:261367
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:139247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8132
    ArfGap; Putative GTPase activating protein for Arf
  4. XM_024450833.1XP_024306601.1  arf-GAP with dual PH domain-containing protein 2 isoform X3

    Conserved Domains (3) summary
    cd13252
    Location:139247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8132
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:254347
    PH-like; Pleckstrin homology-like domain
  5. XM_024450831.1XP_024306599.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

    Related
    ENSP00000464155.1, ENST00000581285.5
    Conserved Domains (3) summary
    cd01251
    Location:255362
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8126
    ArfGap; Putative GTPase activating protein for Arf
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