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METTL2B methyltransferase like 2B [ Homo sapiens (human) ]

Gene ID: 55798, updated on 1-Aug-2020

Summary

Official Symbol
METTL2Bprovided by HGNC
Official Full Name
methyltransferase like 2Bprovided by HGNC
Primary source
HGNC:HGNC:18272
See related
Ensembl:ENSG00000165055 MIM:607846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
METL; METTL2; METTL2A; PSENIP1
Summary
This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See METTL2B in Genome Data Viewer
Location:
7q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (128476748..128506602)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128116783..128142978)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724660 Neighboring gene RNA, U7 small nuclear 54 pseudogene Neighboring gene hypoxia inducible lipid droplet associated Neighboring gene uncharacterized LOC101928451 Neighboring gene ribosomal protein S10 pseudogene 15 Neighboring gene RNA, U6 small nuclear 177, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: HILPDA

Homology

Clone Names

  • FLJ11350, FLJ12760

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tRNA (cytosine) methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA (cytosine-3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA (cytosine-3-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
tRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL2B
Names
methyltransferase-like protein 2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018396.3NP_060866.2  tRNA N(3)-methylcytidine methyltransferase METTL2B

    See identical proteins and their annotated locations for NP_060866.2

    Status: REVIEWED

    Source sequence(s)
    AC010655, AC090114, BC064929, BP247182
    Consensus CDS
    CCDS5803.2
    UniProtKB/Swiss-Prot
    Q6P1Q9
    Related
    ENSP00000262432.8, ENST00000262432.12

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    128476748..128506602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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