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TXLNG taxilin gamma [ Homo sapiens (human) ]

Gene ID: 55787, updated on 5-Apr-2020

Summary

Official Symbol
TXLNGprovided by HGNC
Official Full Name
taxilin gammaprovided by HGNC
Primary source
HGNC:HGNC:18578
See related
Ensembl:ENSG00000086712 MIM:300677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELRG; FIAT; LSR5; TXLNGX; CXorf15
Summary
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in adrenal (RPKM 8.1), fat (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See TXLNG in Genome Data Viewer
Location:
Xp22.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (16786432..16844519)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16804555..16862642)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene synapse associated protein 1 Neighboring gene RNA, U7 small nuclear 56 pseudogene Neighboring gene RB binding protein 7, chromatin remodeling factor Neighboring gene RNA, U4 small nuclear 6, pseudogene Neighboring gene SLC35C2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11209, FLJ33481, MGC126621, MGC126625

Gene Ontology Provided by GOA

Function Evidence Code Pubs
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell cycle process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
gamma-taxilin
Names
environmental LPS-responding
environmental lipopolysaccharide-responding gene protein
factor inhibiting ATF4-mediated transcription
factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription
lipopolysaccharide specific response-5 protein
lipopolysaccharide-specific response protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016267.1 RefSeqGene

    Range
    5035..63088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168683.1NP_001162154.1  gamma-taxilin isoform 2

    See identical proteins and their annotated locations for NP_001162154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA731379, AF143740, AK123142, AW197225, AY739713, DA516680, DB098819
    Consensus CDS
    CCDS55373.1
    UniProtKB/Swiss-Prot
    Q9NUQ3
    Related
    ENSP00000381222.4, ENST00000398155.4
    Conserved Domains (2) summary
    pfam09728
    Location:35313
    Taxilin; Myosin-like coiled-coil protein
    cl19219
    Location:246331
    DUF342; Protein of unknown function (DUF342)
  2. NM_018360.3NP_060830.2  gamma-taxilin isoform 1

    See identical proteins and their annotated locations for NP_060830.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA731379, AF143740, AK123142, AW197225, BC101576, DA516680
    Consensus CDS
    CCDS14178.1
    UniProtKB/Swiss-Prot
    Q9NUQ3
    Related
    ENSP00000369465.5, ENST00000380122.10
    Conserved Domains (2) summary
    pfam09728
    Location:138445
    Taxilin; Myosin-like coiled-coil protein
    cl19219
    Location:378463
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    16786432..16844519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452399.1XP_024308167.1  gamma-taxilin isoform X1

    Conserved Domains (1) summary
    pfam09728
    Location:98405
    Taxilin; Myosin-like coiled-coil protein
  2. XM_024452398.1XP_024308166.1  gamma-taxilin isoform X1

    Conserved Domains (1) summary
    pfam09728
    Location:98405
    Taxilin; Myosin-like coiled-coil protein
  3. XM_024452400.1XP_024308168.1  gamma-taxilin isoform X1

    Conserved Domains (1) summary
    pfam09728
    Location:98405
    Taxilin; Myosin-like coiled-coil protein
  4. XM_017029631.1XP_016885120.1  gamma-taxilin isoform X2

RNA

  1. XR_001755710.1 RNA Sequence

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