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RIOK2 RIO kinase 2 [ Homo sapiens (human) ]

Gene ID: 55781, updated on 5-Sep-2021

Summary

Official Symbol
RIOK2provided by HGNC
Official Full Name
RIO kinase 2provided by HGNC
Primary source
HGNC:HGNC:18999
See related
Ensembl:ENSG00000058729 MIM:617754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIO2
Expression
Ubiquitous expression in thyroid (RPKM 5.0), ovary (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See RIOK2 in Genome Data Viewer
Location:
5q15
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (97160867..97183247, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (96496571..96518951, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SET pseudogene 22 Neighboring gene LIX1 and RIOK2 antisense RNA 1 Neighboring gene limb and CNS expressed 1 Neighboring gene RNA, U1 small nuclear 73, pseudogene Neighboring gene YTH domain family member 1 pseudogene 1 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of preribosome, small subunit precursor IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase RIO2
NP_001153221.1
NP_060813.2
XP_016865117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159749.2NP_001153221.1  serine/threonine-protein kinase RIO2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK225348, DB240299
    Consensus CDS
    CCDS54884.1
    UniProtKB/Swiss-Prot
    Q9BVS4
    Related
    ENSP00000420932.1, ENST00000508447.1
    Conserved Domains (3) summary
    COG0478
    Location:8308
    RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
    cd05144
    Location:94276
    RIO2_C; C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase
    pfam09202
    Location:991
    Rio2_N; Rio2, N-terminal
  2. NM_018343.3NP_060813.2  serine/threonine-protein kinase RIO2 isoform 1

    See identical proteins and their annotated locations for NP_060813.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008865, AK002021, CA415109, DB240299
    Consensus CDS
    CCDS4089.1
    UniProtKB/Swiss-Prot
    Q9BVS4
    Related
    ENSP00000283109.3, ENST00000283109.8
    Conserved Domains (2) summary
    cd05144
    Location:94276
    RIO2_C; C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase
    pfam09202
    Location:991
    Rio2_N; Rio2, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    97160867..97183247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009628.1XP_016865117.1  serine/threonine-protein kinase RIO2 isoform X1

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