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sox14 SRY-box transcription factor 14 [ Danio rerio (zebrafish) ]

Gene ID: 557661, updated on 6-Jul-2026
Official Symbol
sox14provided by ZNC
Official Full Name
SRY-box transcription factor 14provided by ZNC
Primary source
ZFIN:ZDB-GENE-051113-268
See related
Ensembl:ENSDARG00000070929 AllianceGenome:ZFIN:ZDB-GENE-051113-268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:123197
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hypothalamus development. Predicted to be active in nucleus. Is expressed in gonad primordium. Orthologous to human SOX14 (SRY-box transcription factor 14). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See sox14 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (29053764..29055706, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (26557979..26559921, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141386269 Neighboring gene uncharacterized LOC141386270 Neighboring gene uncharacterized LOC137495971 Neighboring gene uncharacterized LOC141386272 Neighboring gene uncharacterized LOC137495972

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention. Hufton AL, et al. Genome Res, 2009 Nov. PMID 19704032, Free PMC Article
  2. sox21a directs lateral line patterning by modulating FGF signaling. Ariza-Cosano A, et al. Dev Neurobiol, 2015 Jan. PMID 25044975
  3. A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs. Yan YL, et al. Genetics, 2021 Feb 9. PMID 33724412, Free PMC Article
  4. Sox Gene Family Revealed Genetic Variations in Autotetraploid Carassius auratus. Huang X, et al. Front Genet, 2020. PMID 32849805, Free PMC Article
  5. Genome wide identification, phylogeny, and synteny analysis of sox gene family in common carp (Cyprinus carpio). Zafar I, et al. Biotechnol Rep (Amst), 2021 Jun. PMID 33936955, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC123197

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hypothalamus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription factor Sox-14
Names
SRY (sex determining region Y)-box 14
SRY-box containing gene 14

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037680.2 → NP_001032769.1  transcription factor Sox-14

    See identical proteins and their annotated locations for NP_001032769.1

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000006
    UniProtKB/Swiss-Prot
    Q32PP9
    Related
    ENSDARP00000095305.3, ENSDART00000104532.5
    Conserved Domains (2) summary
    cd01388
    Location:7 → 78
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12336
    Location:77 → 95
    SOXp; SOX transcription factor

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    29053764..29055706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32PP9.1 GenPept UniProtKB/Swiss-Prot:Q32PP9

Gene LinkOut

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