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EXOC1 exocyst complex component 1 [ Homo sapiens (human) ]

Gene ID: 55763, updated on 7-Jun-2020

Summary

Official Symbol
EXOC1provided by HGNC
Official Full Name
exocyst complex component 1provided by HGNC
Primary source
HGNC:HGNC:30380
See related
Ensembl:ENSG00000090989 MIM:607879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC3; SEC3P; BM-102; SEC3L1
Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.9), skin (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See EXOC1 in Genome Data Viewer
Location:
4q12
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (55853648..55905086)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56719802..56771244)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 276, pseudogene Neighboring gene uncharacterized LOC105377661 Neighboring gene exocyst complex component 1 like Neighboring gene uncharacterized LOC105377663 Neighboring gene RNA, U6 small nuclear 652, pseudogene Neighboring gene centrosomal protein 135 Neighboring gene VISTA enhancer hs1651 Neighboring gene capping protein inhibiting regulator of actin dynamics

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef interacts with EXOC1 and this interaction is dependent on the GTPase interaction site of PAK2 PubMed
nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 1 (EXOC1) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10893

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocyst NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exocyst complex component 1
Names
SEC3-like 1
exocyst complex component Sec3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024924.2NP_001020095.1  exocyst complex component 1 isoform 1

    See identical proteins and their annotated locations for NP_001020095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, as compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC110611, AW589689, BC094751, BM468054
    Consensus CDS
    CCDS3502.1
    UniProtKB/Swiss-Prot
    Q9NV70
    UniProtKB/TrEMBL
    A0A024RDA9
    Related
    ENSP00000370695.2, ENST00000381295.7
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184871
    Sec3_C; Exocyst complex component Sec3
  2. NM_018261.3NP_060731.2  exocyst complex component 1 isoform 1

    See identical proteins and their annotated locations for NP_060731.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AK001755, AW589689, BC094751
    Consensus CDS
    CCDS3502.1
    UniProtKB/Swiss-Prot
    Q9NV70
    UniProtKB/TrEMBL
    A0A024RDA9
    Related
    ENSP00000326514.7, ENST00000346134.11
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184871
    Sec3_C; Exocyst complex component Sec3
  3. NM_178237.2NP_839955.1  exocyst complex component 1 isoform 2

    See identical proteins and their annotated locations for NP_839955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform 2) lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AK027413, AL833208, AW589689, BC094751
    Consensus CDS
    CCDS3503.1
    UniProtKB/Swiss-Prot
    Q9NV70
    UniProtKB/TrEMBL
    A0A024RDA1
    Related
    ENSP00000334431.6, ENST00000349598.6
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184856
    Sec3_C; Exocyst complex component Sec3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    55853648..55905086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265748.1XP_005265805.1  exocyst complex component 1 isoform X1

    See identical proteins and their annotated locations for XP_005265805.1

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184889
    Sec3_C; Exocyst complex component Sec3
  2. XM_017008406.1XP_016863895.1  exocyst complex component 1 isoform X2

  3. XM_017008407.2XP_016863896.1  exocyst complex component 1 isoform X4

  4. XM_005265747.3XP_005265804.1  exocyst complex component 1 isoform X1

    See identical proteins and their annotated locations for XP_005265804.1

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184889
    Sec3_C; Exocyst complex component Sec3
  5. XM_017008405.2XP_016863894.1  exocyst complex component 1 isoform X2

  6. XM_005265750.3XP_005265807.1  exocyst complex component 1 isoform X3

    See identical proteins and their annotated locations for XP_005265807.1

    UniProtKB/TrEMBL
    A0A024RDA1
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184856
    Sec3_C; Exocyst complex component Sec3
  7. XM_017008408.2XP_016863897.1  exocyst complex component 1 isoform X5

  8. XM_017008409.1XP_016863898.1  exocyst complex component 1 isoform X6

    UniProtKB/Swiss-Prot
    Q9NV70
    Conserved Domains (1) summary
    cl19950
    Location:1465
    Sec3_C; Exocyst complex component Sec3

RNA

  1. XR_001741286.1 RNA Sequence

  2. XR_001741285.2 RNA Sequence

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