EXOC1 exocyst complex component 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EXOC1provided by HGNC
Official Full Name: exocyst complex component 1provided by HGNC
Primary source: HGNC:HGNC:30380
See related: Ensembl:ENSG00000090989 MIM:607879; AllianceGenome:HGNC:30380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SEC3; SEC3P; BM-102; SEC3L1
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 10.9), skin (RPKM 9.9) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 4q12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (55853648..55905086)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (59341793..59393237)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (56719814..56771252)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study provides evidence that Sec3 is involved in TGF-beta induced cell migration and epithelial-mesenchymal transition processes, presumably through the regulation of PI3K/Akt signaling activation in A549 cancer cells
Title: Sec3 knockdown inhibits TGF-β induced epithelial-mesenchymal transition through the down-regulation of Akt phosphorylation in A549 cells.
rs13117307 is associated with cervical squamous cell carcinoma. rs13117307 SNP upregulated EXCO1 transcript levels in the non-cancerous cervical and in the cervical SCC tissue.
Title: Role of rs13117307 single nuclear polymorphism in the risk of uterine cervical cancer from Polish population and its impact on exocyst complex component 1 expression.
This study portrayed the non-structural function of C protein that helped the flavivirus to nullify the antiviral activity of hSec3p by accelerating its degradation and facilitating efficient binding of elongation factor 1alpha with flaviviral RNA genome.
Title: West Nile virus and dengue virus capsid protein negates the antiviral activity of human Sec3 protein through the proteasome pathway.
This study identified human Sec3 exocyst protein (hSec3p) as a novel interacting partner of West Nile virus and Dengue virus C protein.
Title: Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus.
Sec3 associates with a subset of Exocyst complexes that are enriched at desmosomes.
Title: Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells.
The exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation.
Title: The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef interacts with EXOC1 and this interaction is dependent on the GTPase interaction site of PAK2	PubMed
	nef	HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 1 (EXOC1) is a Nef-binding protein in Jurkat cells	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-22710 (e-PCR)
- UniSTS:12562

RH98748 (e-PCR)
- UniSTS:84803

SHGC-67788 (e-PCR)
- UniSTS:6793

SHGC-67947 (e-PCR)
- UniSTS:2741

SEC3_1440 (e-PCR)
- UniSTS:277696

SEC3_v479 (e-PCR)
- UniSTS:277696

SHGC-142121 (e-PCR)
- UniSTS:174021

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of macroautophagy	TAS Traceable Author Statement more info	PubMed
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IEA Inferred from Electronic Annotation more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: exocyst complex component 1

Names: SEC3-like 1; exocyst complex component Sec3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024924.2 → NP_001020095.1 exocyst complex component 1 isoform 1

See identical proteins and their annotated locations for NP_001020095.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, as compared to variant 1. Variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AC110611, AW589689, BC094751, BM468054

Consensus CDS

CCDS3502.1

UniProtKB/Swiss-Prot

Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4

Related

ENSP00000370695.2, ENST00000381295.7

Conserved Domains (2) summary

cd14683
Location:3 → 120

PH-EXOC1; PH-like domain of Exocyst complex component 1

pfam09763
Location:184 → 871

Sec3_C; Exocyst complex component Sec3
NM_018261.4 → NP_060731.2 exocyst complex component 1 isoform 1

See identical proteins and their annotated locations for NP_060731.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1). Variants 1 and 3 encode the same protein.

Source sequence(s)

AC110611, AK001755, AW589689, BC094751

Consensus CDS

CCDS3502.1

UniProtKB/Swiss-Prot

Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4

Related

ENSP00000326514.7, ENST00000346134.11

Conserved Domains (2) summary

cd14683
Location:3 → 120

PH-EXOC1; PH-like domain of Exocyst complex component 1

pfam09763
Location:184 → 871

Sec3_C; Exocyst complex component Sec3
NM_178237.3 → NP_839955.1 exocyst complex component 1 isoform 2

See identical proteins and their annotated locations for NP_839955.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform 2) lacks an internal segment and is shorter than isoform 1.

Source sequence(s)

AC110611, AK027413, AL833208, AW589689, BC094751

Consensus CDS

CCDS3503.1

Related

ENSP00000334431.6, ENST00000349598.6

Conserved Domains (2) summary

cd14683
Location:3 → 120

PH-EXOC1; PH-like domain of Exocyst complex component 1

pfam09763
Location:184 → 856

Sec3_C; Exocyst complex component Sec3