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DHX32 DEAH-box helicase 32 (putative) [ Homo sapiens (human) ]

Gene ID: 55760, updated on 13-Mar-2020

Summary

Official Symbol
DHX32provided by HGNC
Official Full Name
DEAH-box helicase 32 (putative)provided by HGNC
Primary source
HGNC:HGNC:16717
See related
Ensembl:ENSG00000089876 MIM:607960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX32; DHLP1
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.2), colon (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See DHX32 in Genome Data Viewer
Location:
10q26.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (125836337..125881292, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127524909..127569884, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene microRNA 4484 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene RNA, U2 small nuclear 42, pseudogene Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene G protein subunit gamma 10 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10694, FLJ10889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
DEAD/H box 32
DEAD/H helicase-like protein-1
DEAH (Asp-Glu-Ala-His) box polypeptide 32
DEAH box protein 32
huDDX32
NP_060650.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018180.3NP_060650.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

    See identical proteins and their annotated locations for NP_060650.2

    Status: REVIEWED

    Source sequence(s)
    AL360176
    Consensus CDS
    CCDS7652.1
    UniProtKB/Swiss-Prot
    Q7L7V1
    Related
    ENSP00000284690.3, ENST00000284690.4
    Conserved Domains (1) summary
    COG1643
    Location:12679
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    125836337..125881292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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