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UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 55757, updated on 10-Dec-2019

Summary

Official Symbol
UGGT2provided by HGNC
Official Full Name
UDP-glucose glycoprotein glucosyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:15664
See related
Ensembl:ENSG00000102595 MIM:605898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGT2; HUGT2; UGCGL2
Summary
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Expression
Ubiquitous expression in thyroid (RPKM 5.5), testis (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See UGGT2 in Genome Data Viewer
Location:
13q32.1
Exon count:
46
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (95801580..96053437, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96453834..96705736, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene MT-CYB pseudogene 3 Neighboring gene uncharacterized LOC105370322 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene Neighboring gene microRNA 4501

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Calnexin/calreticulin cycle, organism-specific biosystem (from REACTOME)
    Calnexin/calreticulin cycle, organism-specific biosystemThe unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and P...
  • ER Quality Control Compartment (ERQC), organism-specific biosystem (from REACTOME)
    ER Quality Control Compartment (ERQC), organism-specific biosystemProteins that are released from the CNX or CRT complex with folding defects accumulate in a compartment of the ER called ERQC (Kamhi-Nesher et al. 2001). Here, the enzymes UGGG1 or UGGG2 are able to ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystem (from REACTOME)
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystemAfter being synthesized in the ER membrane the 14-sugars lipid-linked oligosaccharide is co-translationally transferred to an unfolded protein, as described in the previous steps. After this point th...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10873, FLJ11485, MGC87276, MGC117360, MGC150689

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-glucose:glycoprotein glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-glucosylation IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum mannose trimming TAS
Traceable Author Statement
more info
 
protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum quality control compartment IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-glucose:glycoprotein glucosyltransferase 2
Names
UDP-Glc:glycoprotein glucosyltransferase 2
UDP-glucose ceramide glucosyltransferase-like 1
UDP-glucose ceramide glucosyltransferase-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020121.4NP_064506.3  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_064506.3

    Status: VALIDATED

    Source sequence(s)
    AF227906, AL162500, BC017759, BC032302
    Consensus CDS
    CCDS9480.1
    UniProtKB/Swiss-Prot
    Q9NYU1
    UniProtKB/TrEMBL
    Q05D90
    Related
    ENSP00000365938.3, ENST00000376747.8
    Conserved Domains (2) summary
    cd06432
    Location:12311478
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    95801580..96053437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521097.1XP_011519399.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X4

    Conserved Domains (2) summary
    cd06432
    Location:12581505
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331216
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  2. XM_017020662.1XP_016876151.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X5

  3. XM_011521096.1XP_011519398.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X3

    Conserved Domains (2) summary
    cd06432
    Location:12141461
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331172
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  4. XM_011521095.1XP_011519397.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

    Conserved Domains (2) summary
    cd06432
    Location:12311478
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  5. XM_011521094.1XP_011519396.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

    Conserved Domains (2) summary
    cd06432
    Location:12581505
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331216
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  6. XM_024449384.1XP_024305152.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X6

    Conserved Domains (2) summary
    cd06432
    Location:9381185
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1896
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  7. XM_017020663.1XP_016876152.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X12

  8. XM_024449385.1XP_024305153.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X7

    Conserved Domains (2) summary
    cd06432
    Location:9311178
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:3889
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  9. XM_011521099.2XP_011519401.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X8

    Conserved Domains (2) summary
    cd06432
    Location:9041151
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1862
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  10. XM_011521103.2XP_011519405.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X11

    Conserved Domains (2) summary
    cd06432
    Location:586833
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1544
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  11. XM_011521102.2XP_011519404.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X10

    Conserved Domains (2) summary
    cd06432
    Location:699946
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1657
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  12. XM_011521100.2XP_011519402.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X9

    Conserved Domains (1) summary
    pfam06427
    Location:331013
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RNA

  1. XR_001749630.1 RNA Sequence

  2. XR_931617.1 RNA Sequence

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