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UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 55757, updated on 8-Jul-2021

Summary

Official Symbol
UGGT2provided by HGNC
Official Full Name
UDP-glucose glycoprotein glucosyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:15664
See related
Ensembl:ENSG00000102595 MIM:605898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGT2; HUGT2; UGCGL2
Summary
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Expression
Ubiquitous expression in thyroid (RPKM 5.5), testis (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See UGGT2 in Genome Data Viewer
Location:
13q32.1
Exon count:
46
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (95801580..96053437, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96453834..96705655, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene MT-CYB pseudogene 3 Neighboring gene uncharacterized LOC105370322 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene Neighboring gene microRNA 4501

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10873, FLJ11485, MGC87276, MGC117360, MGC150689

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UDP-glucose:glycoprotein glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables UDP-glucose:glycoprotein glucosyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in UDP-glucosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum mannose trimming TAS
Traceable Author Statement
more info
 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum quality control compartment IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-glucose:glycoprotein glucosyltransferase 2
Names
UDP-Glc:glycoprotein glucosyltransferase 2
UDP-glucose ceramide glucosyltransferase-like 1
UDP-glucose ceramide glucosyltransferase-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020121.4NP_064506.3  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_064506.3

    Status: VALIDATED

    Source sequence(s)
    AF227906, AL162500, BC017759, BC032302
    Consensus CDS
    CCDS9480.1
    UniProtKB/Swiss-Prot
    Q9NYU1
    UniProtKB/TrEMBL
    Q05D90
    Related
    ENSP00000365938.3, ENST00000376747.8
    Conserved Domains (2) summary
    cd06432
    Location:12311478
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    95801580..96053437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521097.1XP_011519399.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X4

    Conserved Domains (2) summary
    cd06432
    Location:12581505
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331216
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  2. XM_017020662.1XP_016876151.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X5

  3. XM_011521096.1XP_011519398.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X3

    Conserved Domains (2) summary
    cd06432
    Location:12141461
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331172
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  4. XM_011521095.1XP_011519397.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

    Conserved Domains (2) summary
    cd06432
    Location:12311478
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  5. XM_011521094.1XP_011519396.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

    Conserved Domains (2) summary
    cd06432
    Location:12581505
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:331216
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  6. XM_024449384.1XP_024305152.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X6

    Conserved Domains (2) summary
    cd06432
    Location:9381185
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1896
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  7. XM_017020663.1XP_016876152.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X12

  8. XM_024449385.1XP_024305153.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X7

    Conserved Domains (2) summary
    cd06432
    Location:9311178
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:3889
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  9. XM_011521099.2XP_011519401.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X8

    Conserved Domains (2) summary
    cd06432
    Location:9041151
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1862
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  10. XM_011521103.2XP_011519405.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X11

    Conserved Domains (2) summary
    cd06432
    Location:586833
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1544
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  11. XM_011521102.2XP_011519404.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X10

    Conserved Domains (2) summary
    cd06432
    Location:699946
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:1657
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  12. XM_011521100.2XP_011519402.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X9

    Conserved Domains (1) summary
    pfam06427
    Location:331013
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RNA

  1. XR_001749630.1 RNA Sequence

  2. XR_931617.1 RNA Sequence

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