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OGDHL oxoglutarate dehydrogenase L [ Homo sapiens (human) ]

Gene ID: 55753, updated on 24-May-2020

Summary

Official Symbol
OGDHLprovided by HGNC
Official Full Name
oxoglutarate dehydrogenase Lprovided by HGNC
Primary source
HGNC:HGNC:25590
See related
Ensembl:ENSG00000197444 MIM:617513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016]
Expression
Biased expression in kidney (RPKM 82.8), liver (RPKM 20.1) and 3 other tissues See more
Orthologs

Genomic context

See OGDHL in Genome Data Viewer
Location:
10q11.23
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49734641..49762379, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50942687..50970425, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 18 member A3 Neighboring gene choline O-acetyltransferase Neighboring gene chromosome 10 open reading frame 53 Neighboring gene mitogen-activated protein kinase 6 pseudogene 6 Neighboring gene ribosomal protein L21 pseudogene 89

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
2-oxoglutarate dehydrogenase-like, mitochondrial
Names
2-oxoglutarate dehydrogenase complex component E1-like
OGDC-E1-like
alpha-ketoglutarate dehydrogenase-like
oxoglutarate dehydrogenase like
NP_001137468.1
NP_001137469.1
NP_001334748.1
NP_001334749.1
NP_001334750.1
NP_001334751.1
NP_001334752.1
NP_001334753.1
NP_001334754.1
NP_001334755.1
NP_060715.2
XP_011538248.1
XP_016871891.1
XP_016871892.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052636.1 RefSeqGene

    Range
    5057..32739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143996.1NP_001137468.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001137468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame internal exon, compared to variant 1, resulting in a shorter isoform (b), compared to isoform a. Variants 2 and 5 both encode the same isoform (b).
    Source sequence(s)
    AK296551, BM504223, BQ549806, DA238469, DA411851
    Consensus CDS
    CCDS44390.1
    UniProtKB/Swiss-Prot
    Q9ULD0
    Related
    ENSP00000401356.1, ENST00000419399.4
    Conserved Domains (5) summary
    PRK09404
    Location:51944
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:194457
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:579793
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:5168
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:800943
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  2. NM_001143997.1NP_001137469.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001137469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a. Variants 3, 6, and 7 all encode the same isoform (c).
    Source sequence(s)
    AK303729, BP209348, BQ549806, DA238469, DA416844
    Consensus CDS
    CCDS44391.1
    UniProtKB/Swiss-Prot
    Q9ULD0
    Related
    ENSP00000390240.1, ENST00000432695.2
    Conserved Domains (4) summary
    PRK09404
    Location:1792
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:42305
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:427641
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16870
    Location:648791
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  3. NM_001347819.1NP_001334748.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AC069546
    Consensus CDS
    CCDS7234.1
    UniProtKB/Swiss-Prot
    Q9ULD0
  4. NM_001347820.1NP_001334749.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC069546
    Consensus CDS
    CCDS44390.1
    UniProtKB/Swiss-Prot
    Q9ULD0
  5. NM_001347821.2NP_001334750.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 3 and 7, encodes isoform c.
    Source sequence(s)
    AC069546
    Consensus CDS
    CCDS44391.1
    UniProtKB/Swiss-Prot
    Q9ULD0
  6. NM_001347822.1NP_001334751.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 3 and 6, encodes isoform c.
    Source sequence(s)
    AC069546
    Consensus CDS
    CCDS44391.1
    UniProtKB/Swiss-Prot
    Q9ULD0
  7. NM_001347823.1NP_001334752.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform d.
    Source sequence(s)
    AC069546
  8. NM_001347824.2NP_001334753.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform d.
    Source sequence(s)
    AC069546
  9. NM_001347825.2NP_001334754.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform e

    Status: REVIEWED

    Source sequence(s)
    AC069546
  10. NM_001347826.1NP_001334755.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform f

    Status: REVIEWED

    Source sequence(s)
    AC069546
  11. NM_018245.3NP_060715.2  2-oxoglutarate dehydrogenase-like, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_060715.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4 both encode the same isoform (a).
    Source sequence(s)
    AB033116, BC026320, BQ549806, DA238469, DA411851
    Consensus CDS
    CCDS7234.1
    UniProtKB/Swiss-Prot
    Q9ULD0
    Related
    ENSP00000363216.4, ENST00000374103.9
    Conserved Domains (5) summary
    PRK09404
    Location:511001
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:251514
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:636850
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:5176
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8571000
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RNA

  1. NR_144682.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546
  2. NR_144683.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546
  3. NR_144684.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546
  4. NR_144685.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546
  5. NR_144686.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49734641..49762379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539946.2XP_011538248.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011538248.1

    UniProtKB/Swiss-Prot
    Q9ULD0
    Conserved Domains (5) summary
    PRK09404
    Location:511001
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:251514
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:636850
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:5176
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8571000
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  2. XM_017016402.1XP_016871891.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform X2

  3. XM_017016403.1XP_016871892.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform X2

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