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AGK acylglycerol kinase [ Homo sapiens (human) ]

Gene ID: 55750, updated on 6-Jul-2025
Official Symbol
AGKprovided by HGNC
Official Full Name
acylglycerol kinaseprovided by HGNC
Primary source
HGNC:HGNC:21869
See related
Ensembl:ENSG00000006530 MIM:610345; AllianceGenome:HGNC:21869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MULK; CATC5; CTRCT38; MTDPS10
Summary
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in heart (RPKM 7.4), brain (RPKM 6.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See AGK in Genome Data Viewer
Location:
7q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141551410..141655244)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (142867231..142971096)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141251210..141355044)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene uncharacterized LOC124901760 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141129896-141130404 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141130405-141130913 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:141181561-141182760 Neighboring gene NANOG hESC enhancer GRCh37_chr7:141184837-141185338 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:141190238-141190791 Neighboring gene MPRA-validated peak6797 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18717 Neighboring gene AGK divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141284163-141284720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:141284721-141285276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141285835-141286391 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:141286949-141287505 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:141374567-141375546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141391618-141392127 Neighboring gene DENN domain containing 11 Neighboring gene MPRA-validated peak6798 silencer Neighboring gene WEE2 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 82, pseudogene Neighboring gene WEE2 oocyte meiosis inhibiting kinase

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ10842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables acylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ceramide kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein insertion into mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TIM22 mitochondrial import inner membrane insertion complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
acylglycerol kinase, mitochondrial
Names
hAGK
hsMuLK
multi-substrate lipid kinase
multiple substrate lipid kinase
NP_001351877.1
NP_060708.1
XP_011514699.1
XP_024302603.1
XP_054214618.1
XP_054214619.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032079.1 RefSeqGene

    Range
    5133..108967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1251

mRNA and Protein(s)

  1. NM_001364948.3NP_001351877.1  acylglycerol kinase, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure resulting in a novel 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, and has a novel C-terminus, compared to isoform 1
    Source sequence(s)
    AC004918, AC073878, AC099547
    Consensus CDS
    CCDS94220.1
    UniProtKB/TrEMBL
    A0A3B3ISZ0, E9PC15
    Related
    ENSP00000497457.1, ENST00000650006.1
    Conserved Domains (1) summary
    pfam00781
    Location:62195
    DAGK_cat; Diacylglycerol kinase catalytic domain
  2. NM_018238.4NP_060708.1  acylglycerol kinase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_060708.1

    Status: REVIEWED

    Description
    Transcript Variant: The variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AJ278150, AK001704, AW961934, BC022777, BU740733
    Consensus CDS
    CCDS5865.1
    UniProtKB/Swiss-Prot
    Q53H12, Q75KN1, Q96GC3, Q9NP48
    UniProtKB/TrEMBL
    A4D1U5, E9PC15
    Related
    ENSP00000497280.1, ENST00000649286.2
    Conserved Domains (1) summary
    pfam00781
    Location:62195
    DAGK_cat; Diacylglycerol kinase catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    141551410..141655244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446835.2XP_024302603.1  acylglycerol kinase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q53H12, Q75KN1, Q96GC3, Q9NP48
    UniProtKB/TrEMBL
    A4D1U5, E9PC15
    Related
    ENSP00000496789.1, ENST00000650547.1
    Conserved Domains (1) summary
    pfam00781
    Location:62195
    DAGK_cat; Diacylglycerol kinase catalytic domain
  2. XM_011516397.4XP_011514699.1  acylglycerol kinase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011514699.1

    UniProtKB/Swiss-Prot
    Q53H12, Q75KN1, Q96GC3, Q9NP48
    UniProtKB/TrEMBL
    A4D1U5, E9PC15
    Conserved Domains (1) summary
    pfam00781
    Location:62195
    DAGK_cat; Diacylglycerol kinase catalytic domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315922.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    476..21836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    142867231..142971096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358644.1XP_054214619.1  acylglycerol kinase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q53H12, Q75KN1, Q96GC3, Q9NP48
    UniProtKB/TrEMBL
    A4D1U5, E9PC15
  2. XM_054358643.1XP_054214618.1  acylglycerol kinase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q53H12, Q75KN1, Q96GC3, Q9NP48
    UniProtKB/TrEMBL
    A4D1U5, E9PC15