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CNDP2 carnosine dipeptidase 2 [ Homo sapiens (human) ]

Gene ID: 55748, updated on 4-Jun-2020

Summary

Official Symbol
CNDP2provided by HGNC
Official Full Name
carnosine dipeptidase 2provided by HGNC
Primary source
HGNC:HGNC:24437
See related
Ensembl:ENSG00000133313 MIM:169800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CN2; CPGL; PEPA; HsT2298; HEL-S-13
Summary
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 58.4), small intestine (RPKM 41.5) and 24 other tissues See more
Orthologs

Genomic context

See CNDP2 in Genome Data Viewer
Location:
18q22.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (74496363..74523454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72163500..72190689)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr18.1476 Neighboring gene divergent protein kinase domain 1C Neighboring gene carnosine dipeptidase 1 Neighboring gene long intergenic non-protein coding RNA 909 Neighboring gene zinc finger protein 407

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10830, FLJ35544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alanylglutamate dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
cytosolic dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
glutathione biosynthetic process TAS
Traceable Author Statement
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytosolic non-specific dipeptidase
Names
CNDP dipeptidase 2 (metallopeptidase M20 family)
carnosinase-2
carnosine dipeptidase II
cytosolic nonspecific dipeptidase
epididymis secretory protein Li 13
glutamate carboxypeptidase-like protein 1
peptidase A
NP_001161971.1
NP_001357177.1
NP_001357178.1
NP_001357179.1
NP_001357183.1
NP_060705.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168499.1NP_001161971.1  cytosolic non-specific dipeptidase isoform 2

    See identical proteins and their annotated locations for NP_001161971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC009704, AF258592, BM675304, DC392026
    Consensus CDS
    CCDS54190.1
    UniProtKB/Swiss-Prot
    Q96KP4
    Related
    ENSP00000325756.8, ENST00000324301.12
    Conserved Domains (2) summary
    PRK08201
    Location:10389
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:7389
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
  2. NM_001370248.1NP_001357177.1  cytosolic non-specific dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, BQ223281
    Related
    ENSP00000462311.1, ENST00000579847.5
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
  3. NM_001370249.1NP_001357178.1  cytosolic non-specific dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, BQ223281
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
  4. NM_001370250.1NP_001357179.1  cytosolic non-specific dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, BQ223281
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
  5. NM_001370254.1NP_001357183.1  cytosolic non-specific dipeptidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, DC313148
    Conserved Domains (1) summary
    cl14876
    Location:1234
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  6. NM_018235.3NP_060705.2  cytosolic non-specific dipeptidase isoform 1

    See identical proteins and their annotated locations for NP_060705.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AC009704, BC001375, BM675304, DC313148
    Consensus CDS
    CCDS12006.1
    UniProtKB/Swiss-Prot
    Q96KP4
    Related
    ENSP00000325548.4, ENST00000324262.9
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    74496363..74523454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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