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PARVA parvin alpha [ Homo sapiens (human) ]

Gene ID: 55742, updated on 23-Sep-2018

Summary

Official Symbol
PARVAprovided by HGNC
Official Full Name
parvin alphaprovided by HGNC
Primary source
HGNC:HGNC:14652
See related
Ensembl:ENSG00000197702 MIM:608120; Vega:OTTHUMG00000165778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MXRA2; CH-ILKBP
Summary
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in endometrium (RPKM 30.7), fat (RPKM 26.7) and 24 other tissues See more
Orthologs

Genomic context

See PARVA in Genome Data Viewer
Location:
11p15.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (12376441..12535356)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (12397988..12556903)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 2 Neighboring gene uncharacterized LOC107984312 Neighboring gene MICAL C-terminal like Neighboring gene uncharacterized LOC105376556 Neighboring gene TEAD1 intron CAGE-defined low expression enhancers Neighboring gene TEA domain transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of parvin, alpha (PARVA) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10793, FLJ12254, FLJ25106, FLJ46049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin-mediated cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-parvin
Names
actopaxin
calponin-like integrin-linked kinase-binding protein
matrix-remodeling-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018222.5NP_060692.3  alpha-parvin

    Status: REVIEWED

    Source sequence(s)
    AC009806, AK001655, CA444306, DC344546
    Consensus CDS
    CCDS44541.2
    Related
    ENSP00000334008.8, ENST00000334956.12
    Conserved Domains (1) summary
    pfam00307
    Location:95203
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    12376441..12535356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253015.3XP_005253072.1  alpha-parvin isoform X1

    Conserved Domains (1) summary
    pfam00307
    Location:52153
    CH; Calponin homology (CH) domain
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