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cox8a cytochrome c oxidase subunit 8A [ Danio rerio (zebrafish) ]

Gene ID: 557348, updated on 4-Jan-2025

Summary

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Official Symbol
cox8aprovided by ZNC
Official Full Name
cytochrome c oxidase subunit 8Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9136
See related
Ensembl:ENSDARG00000095273 AllianceGenome:ZFIN:ZDB-GENE-030131-9136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb01d11; coxXVIII; zehn2228; wu:fb01d11; hm:zehn2228
Summary
Predicted to act upstream of or within mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Is expressed in brain; gill; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 15. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See cox8a in Genome Data Viewer
Location:
chromosome: 21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (28496193..28500703)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (28459498..28464008)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene phosphorylase, glycogen, muscle A Neighboring gene solute carrier family 22 member 6, like Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1a Neighboring gene ependymin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP. Kim MJ, et al. Biotechniques, 2008 Sep. PMID 18778258
  2. A novel approach to study motor neurons from zebrafish embryos and larvae in culture. Sakowski SA, et al. J Neurosci Methods, 2012 Apr 15. PMID 22285259, Free PMC Article
  3. Enhanced antidiabetic efficacy and safety of compound K⁄β-cyclodextrin inclusion complex in zebrafish. Nam YH, et al. J Ginseng Res, 2017 Jan. PMID 28123328, Free PMC Article
  4. Nanoplastics Decrease the Toxicity of a Complex PAH Mixture but Impair Mitochondrial Energy Production in Developing Zebrafish. Trevisan R, et al. Environ Sci Technol, 2019 Jul 16. PMID 31259535, Free PMC Article
  5. Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish. Choi Y, et al. Anim Cells Syst (Seoul), 2021 Feb 11. PMID 33717419, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 8A, mitochondrial
Names
cytochrome c oxidase subunit VIIIA (ubiquitous)
NP_001289982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303053.1 → NP_001289982.1  cytochrome c oxidase subunit 8A, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    CR749775, EH442681, EH443530
    UniProtKB/TrEMBL
    A0A8M1P768, E9QFA6
    Related
    ENSDARP00000119314.1, ENSDART00000138236.2
    Conserved Domains (1) summary
    pfam02285
    Location:29 → 69
    COX8; Cytochrome oxidase c subunit VIII

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    28496193..28500703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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