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ZFP64 ZFP64 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 55734, updated on 6-Jan-2019

Summary

Official Symbol
ZFP64provided by HGNC
Official Full Name
ZFP64 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:15940
See related
Ensembl:ENSG00000020256 MIM:618111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF338
Expression
Ubiquitous expression in testis (RPKM 2.7), ovary (RPKM 2.2) and 25 other tissues See more
Orthologs

Genomic context

See ZFP64 in Genome Data Viewer
Location:
20q13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (52084011..52191985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (50700550..50808524, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 347, pseudogene Neighboring gene RNA, U7 small nuclear 6 pseudogene Neighboring gene uncharacterized LOC105372664 Neighboring gene endoplasmic reticulum lumenal protein 29 pseudogene 1 Neighboring gene uncharacterized LOC105372666 Neighboring gene uncharacterized LOC107985427 Neighboring gene uncharacterized LOC105372667

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 64
Names
zinc finger protein 338
zinc finger protein 64 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319146.1NP_001306075.1  zinc finger protein 64 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the use of a downstream promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 4. These differences cause translation initiation at an alternate start codon and result in an isoform (e) with a shorter and distinct N-terminus compared to isoform d.
    Source sequence(s)
    AK022690, BC021087, DA731353
    Consensus CDS
    CCDS82630.1
    UniProtKB/Swiss-Prot
    Q9NTW7
    Related
    ENSP00000360578.4, ENST00000371523.8
    Conserved Domains (3) summary
    COG5048
    Location:95226
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113133
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:278298
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_018197.3NP_060667.2  zinc finger protein 64 isoform a

    See identical proteins and their annotated locations for NP_060667.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks several exons and includes an alternate 3' terminal exon resulting in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (a) has a longer and distinct C-terminus compared to isoform d.
    Source sequence(s)
    AK001744, BC041622
    Consensus CDS
    CCDS13440.1
    UniProtKB/Swiss-Prot
    Q9NPA5
    Related
    ENSP00000216923.4, ENST00000216923.4
    Conserved Domains (4) summary
    COG5048
    Location:151450
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:177197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:161186
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:425450
    zf-C2H2_6; C2H2-type zinc finger
  3. NM_022088.4NP_071371.3  zinc finger protein 64 isoform b

    See identical proteins and their annotated locations for NP_071371.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, lacks several exons and includes an alternate 3' terminal exon resulting in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform d.
    Source sequence(s)
    AK001744, BC012759
    Consensus CDS
    CCDS13441.1
    UniProtKB/Swiss-Prot
    Q9NPA5
    Related
    ENSP00000344615.4, ENST00000346617.8
    Conserved Domains (4) summary
    COG5048
    Location:97396
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:123143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:107132
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:371396
    zf-C2H2_6; C2H2-type zinc finger
  4. NM_199426.1NP_955458.1  zinc finger protein 64 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, lacks several exons, and includes an alternate 3' terminal exon resulting in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (c) is longer and has a distinct C-terminus compared to isoform d.
    Source sequence(s)
    AK001744, BC012759, BC031524, BC041622
    Consensus CDS
    CCDS13442.1
    UniProtKB/Swiss-Prot
    Q9NPA5
    Related
    ENSP00000360570.4, ENST00000371515.8
    Conserved Domains (4) summary
    COG5048
    Location:149448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159184
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:423448
    zf-C2H2_6; C2H2-type zinc finger
  5. NM_199427.2NP_955459.2  zinc finger protein 64 isoform d

    See identical proteins and their annotated locations for NP_955459.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform d.
    Source sequence(s)
    AL109984, BC012759, BC021087
    Consensus CDS
    CCDS13439.1
    UniProtKB/Swiss-Prot
    Q9NPA5, Q9NTW7
    Related
    ENSP00000355179.2, ENST00000361387.6
    Conserved Domains (3) summary
    COG5048
    Location:172603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:177197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    52084011..52191985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027947.2XP_016883436.1  zinc finger protein 64 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:118549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:123143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:262287
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006723822.2XP_006723885.1  zinc finger protein 64 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:117248
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:135155
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:119144
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027945.2XP_016883434.1  zinc finger protein 64 isoform X1

  4. XM_017027949.1XP_016883438.1  zinc finger protein 64 isoform X4

    UniProtKB/TrEMBL
    B3KQX0
    Conserved Domains (4) summary
    COG5048
    Location:26292
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1939
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:267292
    zf-C2H2_6; C2H2-type zinc finger
  5. XM_011528900.2XP_011527202.1  zinc finger protein 64 isoform X4

    See identical proteins and their annotated locations for XP_011527202.1

    UniProtKB/TrEMBL
    B3KQX0
    Conserved Domains (4) summary
    COG5048
    Location:26292
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1939
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:267292
    zf-C2H2_6; C2H2-type zinc finger
  6. XM_005260449.1XP_005260506.1  zinc finger protein 64 isoform X4

    See identical proteins and their annotated locations for XP_005260506.1

    UniProtKB/TrEMBL
    B3KQX0
    Conserved Domains (4) summary
    COG5048
    Location:26292
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1939
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:267292
    zf-C2H2_6; C2H2-type zinc finger
  7. XM_017027946.2XP_016883435.1  zinc finger protein 64 isoform X2

  8. XM_017027948.2XP_016883437.1  zinc finger protein 64 isoform X4

    UniProtKB/TrEMBL
    B3KQX0
    Conserved Domains (4) summary
    COG5048
    Location:26292
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1939
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:267292
    zf-C2H2_6; C2H2-type zinc finger
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