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FAM222B family with sequence similarity 222 member B [ Homo sapiens (human) ]

Gene ID: 55731, updated on 13-Mar-2020

Summary

Official Symbol
FAM222Bprovided by HGNC
Official Full Name
family with sequence similarity 222 member Bprovided by HGNC
Primary source
HGNC:HGNC:25563
See related
Ensembl:ENSG00000173065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf63
Expression
Broad expression in testis (RPKM 12.8), duodenum (RPKM 3.8) and 24 other tissues See more
Orthologs

Genomic context

See FAM222B in Genome Data Viewer
Location:
17q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28755979..28854985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27082996..27169857, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11843 Neighboring gene NIMA related kinase 8 Neighboring gene TNF receptor associated factor 4 Neighboring gene ribosomal protein L31 pseudogene 58 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene Era like 12S mitochondrial rRNA chaperone 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10700

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein FAM222B
Names
uncharacterized protein C17orf63

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077498.3NP_001070966.1  protein FAM222B isoform 2

    See identical proteins and their annotated locations for NP_001070966.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, AK057665, BC021228
    Consensus CDS
    CCDS45637.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    A0A024QZ60, B3KQ88
    Related
    ENSP00000462419.1, ENST00000581407.5
    Conserved Domains (1) summary
    pfam15258
    Location:27561
    FAM222A; Protein family of FAM222A
  2. NM_001288631.2NP_001275560.1  protein FAM222B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC010761, BC021228, DA789853
    UniProtKB/Swiss-Prot
    Q8WU58
    Conserved Domains (2) summary
    pfam14650
    Location:163214
    FAM75; FAM75 family
    pfam15258
    Location:31564
    FAM222A; Protein family of FAM222A
  3. NM_001288632.2NP_001275561.1  protein FAM222B isoform 2

    See identical proteins and their annotated locations for NP_001275561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, DB453514, HY040104
    Consensus CDS
    CCDS45637.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    A0A024QZ60
    Conserved Domains (1) summary
    pfam15258
    Location:27561
    FAM222A; Protein family of FAM222A
  4. NM_001288633.2NP_001275562.1  protein FAM222B isoform 2

    See identical proteins and their annotated locations for NP_001275562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, HY012898
    Consensus CDS
    CCDS45637.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    A0A024QZ60
    Conserved Domains (1) summary
    pfam15258
    Location:27561
    FAM222A; Protein family of FAM222A
  5. NM_001288634.2NP_001275563.1  protein FAM222B isoform 2

    See identical proteins and their annotated locations for NP_001275563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate 5' terminal exon, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, AK095569, BC021228
    Consensus CDS
    CCDS45637.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    A0A024QZ60, B3KTH5
    Related
    ENSP00000413645.3, ENST00000452648.7
    Conserved Domains (1) summary
    pfam15258
    Location:27561
    FAM222A; Protein family of FAM222A
  6. NM_001288635.2NP_001275564.1  protein FAM222B isoform 2

    See identical proteins and their annotated locations for NP_001275564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, DC381712, HY040104
    Consensus CDS
    CCDS45637.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    A0A024QZ60
    Conserved Domains (1) summary
    pfam15258
    Location:27561
    FAM222A; Protein family of FAM222A
  7. NM_001288636.2NP_001275565.1  protein FAM222B isoform 3

    See identical proteins and their annotated locations for NP_001275565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, HY006495
    Consensus CDS
    CCDS74022.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  8. NM_001288637.2NP_001275566.1  protein FAM222B isoform 3

    See identical proteins and their annotated locations for NP_001275566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, DA887444
    Consensus CDS
    CCDS74022.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    B4DRX9
    Related
    ENSP00000343115.6, ENST00000341217.6
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  9. NM_001288638.2NP_001275567.1  protein FAM222B isoform 3

    See identical proteins and their annotated locations for NP_001275567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, DC400943, HY040104
    Consensus CDS
    CCDS74022.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  10. NM_001288639.2NP_001275568.1  protein FAM222B isoform 3

    See identical proteins and their annotated locations for NP_001275568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, DC376581, HY040104
    Consensus CDS
    CCDS74022.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  11. NM_001288640.2NP_001275569.1  protein FAM222B isoform 3

    See identical proteins and their annotated locations for NP_001275569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, AK299477, BC021228, HY040104
    Consensus CDS
    CCDS74022.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  12. NM_018182.4NP_060652.2  protein FAM222B isoform 2

    See identical proteins and their annotated locations for NP_060652.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010761, BC021228, DC374179, HY040104
    Consensus CDS
    CCDS45637.1
    UniProtKB/Swiss-Prot
    Q8WU58
    UniProtKB/TrEMBL
    A0A024QZ60
    Conserved Domains (1) summary
    pfam15258
    Location:27561
    FAM222A; Protein family of FAM222A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28755979..28854985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524987.1XP_011523289.1  protein FAM222B isoform X1

    See identical proteins and their annotated locations for XP_011523289.1

    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  2. XM_011524986.2XP_011523288.1  protein FAM222B isoform X1

    See identical proteins and their annotated locations for XP_011523288.1

    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  3. XM_011524988.2XP_011523290.1  protein FAM222B isoform X1

    See identical proteins and their annotated locations for XP_011523290.1

    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
  4. XM_017024835.2XP_016880324.1  protein FAM222B isoform X1

    UniProtKB/TrEMBL
    B4DRX9
    Conserved Domains (1) summary
    pfam15258
    Location:1433
    FAM222A; Protein family of FAM222A
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