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N4BP2 NEDD4 binding protein 2 [ Homo sapiens (human) ]

Gene ID: 55728, updated on 23-Nov-2021

Summary

Official Symbol
N4BP2provided by HGNC
Official Full Name
NEDD4 binding protein 2provided by HGNC
Primary source
HGNC:HGNC:29851
See related
Ensembl:ENSG00000078177 MIM:619139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B3BP
Summary
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in thyroid (RPKM 3.3), lymph node (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See N4BP2 in Genome Data Viewer
Location:
4p14
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (40056223..40187039)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (40058470..40159872)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene PDS5 cohesin associated factor A Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 1 Neighboring gene keratin 18 pseudogene 25 Neighboring gene acyl-CoA thioesterase 7 pseudogene Neighboring gene RNA, U6 small nuclear 1112, pseudogene Neighboring gene ras homolog family member H Neighboring gene long intergenic non-protein coding RNA 2265

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10680, KIAA1413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables polydeoxyribonucleotide 5'-hydroxyl-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NEDD4-binding protein 2
Names
BCL-3-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318359.2NP_001305288.1  NEDD4-binding protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB371584, AC095057, AC098591, AK001542, AU129951, AW135590
    UniProtKB/Swiss-Prot
    Q86UW6
    UniProtKB/TrEMBL
    B2ZZ87
    Conserved Domains (3) summary
    smart00463
    Location:16081690
    SMR; Small MutS-related domain
    pfam08590
    Location:15411600
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:369495
    AAA_33; AAA domain
  2. NM_018177.6NP_060647.2  NEDD4-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060647.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB371584, AC095057, AC098591, AK001542, AW135590, BC126466
    Consensus CDS
    CCDS3457.1
    UniProtKB/Swiss-Prot
    Q86UW6
    UniProtKB/TrEMBL
    B2ZZ87
    Related
    ENSP00000261435.6, ENST00000261435.11
    Conserved Domains (4) summary
    smart00463
    Location:16881770
    SMR; Small MutS-related domain
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16211680
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:449575
    AAA_33; AAA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    40056223..40187039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008397.1XP_016863886.1  NEDD4-binding protein 2 isoform X2

  2. XM_011513717.2XP_011512019.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011512019.1

    Conserved Domains (3) summary
    smart00463
    Location:18201902
    SMR; Small MutS-related domain
    pfam08590
    Location:17531812
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:581707
    AAA_33; AAA domain
  3. XM_011513716.2XP_011512018.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011512018.1

    Conserved Domains (3) summary
    smart00463
    Location:18201902
    SMR; Small MutS-related domain
    pfam08590
    Location:17531812
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:581707
    AAA_33; AAA domain
  4. XM_011513719.2XP_011512021.1  NEDD4-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011512021.1

    Conserved Domains (3) summary
    smart00463
    Location:16081690
    SMR; Small MutS-related domain
    pfam08590
    Location:15411600
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:369495
    AAA_33; AAA domain
  5. XM_017008399.1XP_016863888.1  NEDD4-binding protein 2 isoform X4

    Conserved Domains (3) summary
    smart00463
    Location:16081690
    SMR; Small MutS-related domain
    pfam08590
    Location:15411600
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:369495
    AAA_33; AAA domain
  6. XM_006714023.3XP_006714086.1  NEDD4-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714086.1

    Related
    ENSP00000426430.1, ENST00000513269.1
    Conserved Domains (3) summary
    smart00463
    Location:16081690
    SMR; Small MutS-related domain
    pfam08590
    Location:15411600
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:369495
    AAA_33; AAA domain
  7. XM_011513718.2XP_011512020.1  NEDD4-binding protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011512020.1

    UniProtKB/Swiss-Prot
    Q86UW6
    Conserved Domains (4) summary
    smart00463
    Location:16881770
    SMR; Small MutS-related domain
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16211680
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:449575
    AAA_33; AAA domain
  8. XM_017008398.1XP_016863887.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q86UW6
    Conserved Domains (4) summary
    smart00463
    Location:16881770
    SMR; Small MutS-related domain
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16211680
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:449575
    AAA_33; AAA domain
  9. XM_011513720.1XP_011512022.1  NEDD4-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011512022.1

    Conserved Domains (3) summary
    smart00463
    Location:16081690
    SMR; Small MutS-related domain
    pfam08590
    Location:15411600
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:369495
    AAA_33; AAA domain
  10. XM_011513721.1XP_011512023.1  NEDD4-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011512023.1

    Conserved Domains (3) summary
    smart00463
    Location:16081690
    SMR; Small MutS-related domain
    pfam08590
    Location:15411600
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:369495
    AAA_33; AAA domain

RNA

  1. XR_001741283.1 RNA Sequence

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