U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

antxr2a ANTXR cell adhesion molecule 2a [ Danio rerio (zebrafish) ]

Gene ID: 557239, updated on 16-Jun-2026
Official Symbol
antxr2aprovided by ZNC
Official Full Name
ANTXR cell adhesion molecule 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-14
See related
Ensembl:ENSDARG00000104118 AllianceGenome:ZFIN:ZDB-GENE-060526-14
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-116k3.1
Summary
Enables actin binding activity and small GTPase binding activity. Acts upstream of or within establishment of mitotic spindle orientation. Located in several cellular components, including cleavage furrow; cortical actin cytoskeleton; and midbody. Is expressed in epiblast. Human ortholog(s) of this gene implicated in fibroma and hyaline fibromatosis syndrome. Orthologous to human ANTXR2 (ANTXR cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See antxr2a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (40298361..40383389, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (39389079..39473982, complement)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene BMP2 inducible kinase Neighboring gene progestin and adipoQ receptor family member IIIa Neighboring gene uncharacterized LOC137491368 Neighboring gene PR domain containing 8b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Bolcome RE 3rd, et al. Proc Natl Acad Sci U S A, 2008 Feb 19. PMID 18268319, Free PMC Article
  2. Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis. Bürgi J, et al. Dev Cell, 2020 May 18. PMID 32428455
  3. Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish. Castanon I, et al. Nat Commun, 2020 Jul 3. PMID 32620775, Free PMC Article
  4. Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. O'Connor MN, et al. Blood, 2009 May 7. PMID 19109564, Free PMC Article
  5. Evolution of follistatin in teleosts revealed through phylogenetic, genomic and expression analyses. Macqueen DJ, et al. Dev Genes Evol, 2008 Jan. PMID 18074148

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Preferred Names
anthrax toxin receptor 2
Names
ATR2-a
anthrax toxin receptor 2a
cmg2a

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044709.2 → NP_001038174.2  anthrax toxin receptor 2 precursor

    See identical proteins and their annotated locations for NP_001038174.2

    Status: PROVISIONAL

    Source sequence(s)
    BC139636
    UniProtKB/TrEMBL
    A0A8M1N989, A4QP34
    Related
    ENSDARP00000135609.1, ENSDART00000171557.2
    Conserved Domains (3) summary
    cd01474
    Location:31 → 212
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:385 → 477
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:214 → 307
    Anth_Ig; Anthrax receptor extracellular domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    40298361..40383389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073950470.1 → XP_073806571.1  anthrax toxin receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0AC58JJA6

RNA

  1. XR_012405936.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools