adrb1 adrenoceptor beta 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adrb1provided by ZNC
Official Full Name: adrenoceptor beta 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-081022-145
See related: Ensembl:ENSDARG00000007490 AllianceGenome:ZFIN:ZDB-GENE-081022-145
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:194728; zgc:194731
Summary: Predicted to enable beta1-adrenergic receptor activity. Acts upstream of or within regulation of heart rate and venous blood vessel morphogenesis. Predicted to be located in early endosome and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; eye; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	12	NC_133187.1 (32238810..32240030, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (30442342..30443562, complement)

Chromosome 12 - NC_133187.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adrb1 and Adrb2b are the major beta-adrenergic receptors regulating body axis straightening in zebrafish.
Title: Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish.
Zebrafish larvae lacking beta1AR expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
Title: In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables beta1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within venous blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1 adrenergic receptor

Names: adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; tripartite motif-containing 75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.