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POLR3E RNA polymerase III subunit E [ Homo sapiens (human) ]

Gene ID: 55718, updated on 1-Jun-2020

Summary

Official Symbol
POLR3Eprovided by HGNC
Official Full Name
RNA polymerase III subunit Eprovided by HGNC
Primary source
HGNC:HGNC:30347
See related
Ensembl:ENSG00000058600 MIM:617815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C37; SIN; RPC5
Expression
Ubiquitous expression in prostate (RPKM 6.2), thyroid (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See POLR3E in Genome Data Viewer
Location:
16p12.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (22297375..22335103)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22308696..22346424)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 198 Neighboring gene eukaryotic elongation factor 2 kinase Neighboring gene tRNA-Leu (anticodon AAG) 2-4 Neighboring gene cerebellar degeneration related protein 2 Neighboring gene uncharacterized LOC440346

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC5
Names
DNA-directed RNA polymerase III 80 kDa polypeptide
RNA polymerase III 80 kDa subunit RPC5
RNA polymerase III subunit C5
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
polymerase (RNA) III subunit E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258033.2NP_001244962.1  DNA-directed RNA polymerase III subunit RPC5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AK300735, AW205673
    Consensus CDS
    CCDS58432.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000456967.1, ENST00000564209.5
    Conserved Domains (1) summary
    pfam04801
    Location:5432
    Sin_N; Sin-like protein conserved region
  2. NM_001258034.2NP_001244963.1  DNA-directed RNA polymerase III subunit RPC5 isoform 4

    See identical proteins and their annotated locations for NP_001244963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses an alternate acceptor splice site in the 5' region compared to variant 1, However, it maintains the reading frame, and encodes an isoform (4) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK222671, AK296813, AW205673, DB047155
    Consensus CDS
    CCDS58434.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000399254.2, ENST00000418581.6
    Conserved Domains (1) summary
    pfam04801
    Location:5396
    Sin_N; Sin-like protein conserved region
  3. NM_001258035.1NP_001244964.1  DNA-directed RNA polymerase III subunit RPC5 isoform 3

    See identical proteins and their annotated locations for NP_001244964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region compared to variant 1, which results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK023231, AK222671, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS73845.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    UniProtKB/TrEMBL
    A0A0C4DH01
    Related
    ENSP00000484648.1, ENST00000615879.4
    Conserved Domains (1) summary
    pfam04801
    Location:1396
    Sin_N; Sin-like protein conserved region
  4. NM_001258036.2NP_001244965.1  DNA-directed RNA polymerase III subunit RPC5 isoform 5

    See identical proteins and their annotated locations for NP_001244965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (5) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AW205673
    Consensus CDS
    CCDS58433.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000352140.4, ENST00000359210.8
    Conserved Domains (1) summary
    pfam04801
    Location:5432
    Sin_N; Sin-like protein conserved region
  5. NM_018119.4NP_060589.1  DNA-directed RNA polymerase III subunit RPC5 isoform 1

    See identical proteins and their annotated locations for NP_060589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AW205673
    Consensus CDS
    CCDS10605.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000299853.5, ENST00000299853.10
    Conserved Domains (1) summary
    pfam04801
    Location:5432
    Sin_N; Sin-like protein conserved region

RNA

  1. NR_047581.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate acceptor splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AK293300, AW205673

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    22297375..22335103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545892.2XP_011544194.1  DNA-directed RNA polymerase III subunit RPC5 isoform X1

    Conserved Domains (1) summary
    pfam04801
    Location:5431
    Sin_N; Sin-like protein conserved region
  2. XM_017023443.2XP_016878932.1  DNA-directed RNA polymerase III subunit RPC5 isoform X3

  3. XM_011545893.3XP_011544195.1  DNA-directed RNA polymerase III subunit RPC5 isoform X2

    Related
    ENST00000564061.5
    Conserved Domains (1) summary
    pfam04801
    Location:5432
    Sin_N; Sin-like protein conserved region

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    769927..807655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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