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WDR11 WD repeat domain 11 [ Homo sapiens (human) ]

Gene ID: 55717, updated on 25-Nov-2025
Official Symbol
WDR11provided by HGNC
Official Full Name
WD repeat domain 11provided by HGNC
Primary source
HGNC:HGNC:13831
See related
Ensembl:ENSG00000120008 MIM:606417; AllianceGenome:HGNC:13831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DR11; HH14; SRI1; BRWD2; WDR15
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 17.7), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs
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See WDR11 in Genome Data Viewer
Location:
10q26.12
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (120851362..120909524)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (121747910..121806084)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (122610874..122669036)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1561 Neighboring gene long intergenic non-protein coding RNA 2930 Neighboring gene NANOG hESC enhancer GRCh37_chr10:122404247-122405040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4135 Neighboring gene WDR11 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:122558239-122558907 Neighboring gene H3K27ac hESC enhancers GRCh37_chr10:122610516-122611060 and GRCh37_chr10:122611061-122611604 Neighboring gene uncharacterized LOC105378519 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:122669667-122670866 Neighboring gene Sharpr-MPRA regulatory region 5528 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10489 Neighboring gene uncharacterized LOC105378520 Neighboring gene uncharacterized LOC105378521 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:122784424-122784924 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:122784925-122785425

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication. Taylor KE, et al. J Virol, 2015 Oct. PMID 26178983, Free PMC Article
  2. Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability. Haag N, et al. Eur J Hum Genet, 2021 Nov. PMID 34413497, Free PMC Article
  3. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. Chernova OB, et al. Oncogene, 2001 Aug 30. PMID 11536051
  4. FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26. Katoh M, et al. Int J Oncol, 2003 May. PMID 12684685
  5. Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome. McCormack SE, et al. J Clin Endocrinol Metab, 2017 Jul 1. PMID 28453858, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.
    Title: Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.
  2. Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability.
    Title: Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability.
  3. Our study reveals a novel class of ciliopathy caused by WDR11 mutations and suggests that CHH/KS may be a part of the human ciliopathy spectrum.
    Title: WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
  4. Data indicate a functional link between adaptor protein complex 1 (AP-1) and the WD repeat protein 11 (WDR11) complex.
    Title: The WDR11 complex facilitates the tethering of AP-1-derived vesicles.
  5. WDR11 genetic mutation is responsible for the pathophysiology of pituitary stalk interruption syndrome.
    Title: Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome.
  6. Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.
    Title: Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.
  7. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, causing impaired pubertal development.
    Title: WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  9. Data show that the HTPAPL-WDR11-FGFR2 locus was more susceptible to recombination than to nucleotide substitution.
    Title: Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26.
  10. This gene is expressed on chromosome 10p26.
    Title: FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ42531, DKFZp434L1715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in head development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle tethering to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in lysosomal membrane HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
WD repeat-containing protein 11
Names
WD repeat domain 15
WD repeat-containing protein 15
bromodomain and WD repeat-containing protein 2
sensitization to ricin complex subunit 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023290.1 RefSeqGene

    Range
    5188..63350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018117.12 → NP_060587.8  WD repeat-containing protein 11

    See identical proteins and their annotated locations for NP_060587.8

    Status: REVIEWED

    Source sequence(s)
    BC071564, DC342128
    Consensus CDS
    CCDS7619.1
    UniProtKB/Swiss-Prot
    Q5VWA1, Q9BZH6, Q9P2J6
    UniProtKB/TrEMBL
    B2RCJ6
    Related
    ENSP00000263461.5, ENST00000263461.11
    Conserved Domains (3) summary
    COG2319
    Location:475 → 833
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:714 → 747
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:54 → 179
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    120851362..120909524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269963.3 → XP_005270020.1  WD repeat-containing protein 11 isoform X1

    See identical proteins and their annotated locations for XP_005270020.1

    UniProtKB/TrEMBL
    Q9NVU3
    Conserved Domains (3) summary
    COG2319
    Location:216 → 574
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:455 → 488
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:226 → 561
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_047425458.1 → XP_047281414.1  WD repeat-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q9NVU3

  3. XM_047425459.1 → XP_047281415.1  WD repeat-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q9NVU3

RNA

  1. XR_428707.4 RNA Sequence

  2. XR_007061973.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    121747910..121806084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366270.1 → XP_054222245.1  WD repeat-containing protein 11 isoform X2

  2. XM_054366268.1 → XP_054222243.1  WD repeat-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q9NVU3

  3. XM_054366269.1 → XP_054222244.1  WD repeat-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q9NVU3

RNA

  1. XR_008488227.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZH6.1 GenPept UniProtKB/Swiss-Prot:Q9BZH6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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