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WDR11 WD repeat domain 11 [ Homo sapiens (human) ]

Gene ID: 55717, updated on 24-Nov-2020

Summary

Official Symbol
WDR11provided by HGNC
Official Full Name
WD repeat domain 11provided by HGNC
Primary source
HGNC:HGNC:13831
See related
Ensembl:ENSG00000120008 MIM:606417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DR11; HH14; SRI1; BRWD2; WDR15
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 17.7), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs

Genomic context

See WDR11 in Genome Data Viewer
Location:
10q26.12
Exon count:
30
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (120851313..120909525)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (122610687..122669038)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 4 Neighboring gene long intergenic non-protein coding RNA 1561 Neighboring gene uncharacterized LOC105378516 Neighboring gene WDR11 antisense RNA 1 Neighboring gene uncharacterized LOC105378519 Neighboring gene Sharpr-MPRA regulatory region 5528 Neighboring gene uncharacterized LOC105378518

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Hypogonadotropic hypogonadism 14 with or without anosmia Compare labs
Hypogonadotropic hypogonadism 7 with or without anosmia Compare labs
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42531, DKFZp434L1715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
head development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle tethering to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
lysosomal membrane HDA PubMed 
membrane HDA PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 11
Names
WD repeat domain 15
WD repeat-containing protein 15
bromodomain and WD repeat-containing protein 2
sensitization to ricin complex subunit 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023290.1 RefSeqGene

    Range
    5188..63350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018117.12NP_060587.8  WD repeat-containing protein 11

    See identical proteins and their annotated locations for NP_060587.8

    Status: REVIEWED

    Source sequence(s)
    BC071564, DC342128
    Consensus CDS
    CCDS7619.1
    UniProtKB/Swiss-Prot
    Q9BZH6
    Related
    ENSP00000263461.5, ENST00000263461.11
    Conserved Domains (3) summary
    COG2319
    Location:475833
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:714747
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:54179
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    120851313..120909525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016397.1XP_016871886.1  WD repeat-containing protein 11 isoform X1

  2. XM_017016400.2XP_016871889.1  WD repeat-containing protein 11 isoform X4

  3. XM_005269963.2XP_005270020.1  WD repeat-containing protein 11 isoform X2

    See identical proteins and their annotated locations for XP_005270020.1

    Conserved Domains (3) summary
    COG2319
    Location:216574
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:455488
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:226561
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017016398.1XP_016871887.1  WD repeat-containing protein 11 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:216574
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:455488
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:226561
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_017016399.1XP_016871888.1  WD repeat-containing protein 11 isoform X3

  6. XM_024448075.1XP_024303843.1  WD repeat-containing protein 11 isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:4362
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:243276
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_428707.3 RNA Sequence

  2. XR_001747137.2 RNA Sequence

  3. XR_001747136.2 RNA Sequence

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