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ZNF334 zinc finger protein 334 [ Homo sapiens (human) ]

Gene ID: 55713, updated on 13-Mar-2020

Summary

Official Symbol
ZNF334provided by HGNC
Official Full Name
zinc finger protein 334provided by HGNC
Primary source
HGNC:HGNC:15806
See related
Ensembl:ENSG00000198185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in ovary (RPKM 2.5), brain (RPKM 1.8) and 25 other tissues See more
Orthologs

Genomic context

See ZNF334 in Genome Data Viewer
Location:
20q13.12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (46463660..46513572, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45128269..45142198, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 2 Neighboring gene uncharacterized LOC105372633 Neighboring gene zinc finger protein 663, pseudogene Neighboring gene makorin ring finger protein 7, pseudogene Neighboring gene zinc finger protein 840, pseudogene Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 member 3 Neighboring gene TP53 regulating kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270497.2NP_001257426.1  zinc finger protein 334 isoform c

    See identical proteins and their annotated locations for NP_001257426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK095611, AL034424, AL354745, BC026321
    Consensus CDS
    CCDS74736.1
    UniProtKB/TrEMBL
    A0A087X1P4
    Related
    ENSP00000485779.1, ENST00000625284.2
    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001353813.1NP_001340742.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745, AL833936, BC026321, DA080528
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001353814.1NP_001340743.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001353815.1NP_001340744.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001353816.1NP_001340745.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001353817.1NP_001340746.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001353818.1NP_001340747.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001353819.1NP_001340748.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001353820.1NP_001340749.1  zinc finger protein 334 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    COG5048
    Location:314669
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:4565
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  10. NM_001353821.1NP_001340750.1  zinc finger protein 334 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS74736.1
    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. NM_001353822.1NP_001340751.1  zinc finger protein 334 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS74736.1
    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001353823.1NP_001340752.1  zinc finger protein 334 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS74736.1
    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. NM_001353824.1NP_001340753.1  zinc finger protein 334 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS33480.1
    Conserved Domains (3) summary
    smart00349
    Location:1070
    KRAB; krueppel associated box
    COG5048
    Location:319674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239259
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. NM_001353825.1NP_001340754.1  zinc finger protein 334 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS86959.1
    Conserved Domains (3) summary
    COG5048
    Location:342697
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:7393
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  15. NM_001353826.1NP_001340755.1  zinc finger protein 334 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:1777
    KRAB; krueppel associated box
    COG5048
    Location:326681
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246266
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. NM_018102.5NP_060572.3  zinc finger protein 334 isoform a

    See identical proteins and their annotated locations for NP_060572.3

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745, BC024177, BC026321
    Consensus CDS
    CCDS33480.1
    UniProtKB/Swiss-Prot
    Q9HCZ1
    Related
    ENSP00000255129.5, ENST00000347606.8
    Conserved Domains (3) summary
    smart00349
    Location:1070
    KRAB; krueppel associated box
    COG5048
    Location:319674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239259
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. NM_199441.2NP_955473.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745, BC026321
    Related
    ENSP00000402582.1, ENST00000457685.6
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    46463660..46513572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027944.2XP_016883433.1  zinc finger protein 334 isoform X7

    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:281636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_024451940.1XP_024307708.1  zinc finger protein 334 isoform X4

    Conserved Domains (3) summary
    smart00349
    Location:1070
    KRAB; krueppel associated box
    COG5048
    Location:319674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239259
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_024451943.1XP_024307711.1  zinc finger protein 334 isoform X5

    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_024451939.1XP_024307707.1  zinc finger protein 334 isoform X4

    Conserved Domains (3) summary
    smart00349
    Location:1070
    KRAB; krueppel associated box
    COG5048
    Location:319674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239259
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024451942.1XP_024307710.1  zinc finger protein 334 isoform X5

    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024451937.1XP_024307705.1  zinc finger protein 334 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:3393
    KRAB; krueppel associated box
    COG5048
    Location:342697
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_024451945.1XP_024307713.1  zinc finger protein 334 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:314669
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:4565
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  8. XM_024451941.1XP_024307709.1  zinc finger protein 334 isoform X5

    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_024451944.1XP_024307712.1  zinc finger protein 334 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:314669
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:4565
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  10. XM_024451938.1XP_024307706.1  zinc finger protein 334 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:1777
    KRAB; krueppel associated box
    COG5048
    Location:326681
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246266
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_017027937.1XP_016883426.1  zinc finger protein 334 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:3393
    KRAB; krueppel associated box
    COG5048
    Location:342697
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_017027935.1XP_016883424.1  zinc finger protein 334 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:1777
    KRAB; krueppel associated box
    COG5048
    Location:326681
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246266
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. XM_011528897.2XP_011527199.1  zinc finger protein 334 isoform X5

    See identical proteins and their annotated locations for XP_011527199.1

    UniProtKB/TrEMBL
    A0A087X1P4
    Conserved Domains (3) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:318673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238258
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_011528892.2XP_011527194.1  zinc finger protein 334 isoform X2

    See identical proteins and their annotated locations for XP_011527194.1

    UniProtKB/TrEMBL
    Q8N3P8
    Related
    ENSP00000473194.1, ENST00000593880.1
    Conserved Domains (3) summary
    COG5048
    Location:342697
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:7393
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
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