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raf1b Raf-1 proto-oncogene, serine/threonine kinase b [ Danio rerio (zebrafish) ]

Gene ID: 557109, updated on 9-Sep-2025
Official Symbol
raf1bprovided by ZNC
Official Full Name
Raf-1 proto-oncogene, serine/threonine kinase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090826-2
See related
Ensembl:ENSDARG00000059406 AllianceGenome:ZFIN:ZDB-GENE-090826-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation and signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in brain. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See raf1b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 11 NC_133186.1 (524992..577518)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 11 NC_007122.7 (499365..540240)

Chromosome 11 - NC_133186.1Genomic Context describing neighboring genes Neighboring gene RAB43, member RAS oncogene family Neighboring gene zgc:77375 Neighboring gene ISY1 spliceosome associated protein Neighboring gene CCHC-type zinc finger, nucleic acid binding protein b Neighboring gene makorin, ring finger protein, 2 Neighboring gene MKRN2 opposite strand, tandem duplicate 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Deficiency of leap2 promotes somatic growth in zebrafish: Involvement of the growth hormone system. Guan K, et al. Heliyon, 2024 Sep 30. PMID 39347412, Free PMC Article
  2. Differential expression of synapsin genes during early zebrafish development. Garbarino G, et al. Neuroscience, 2014 Nov 7. PMID 25239370
  3. Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Zhang H, et al. Mar Drugs, 2024 Sep 26. PMID 39452847, Free PMC Article
  4. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. Encinas P, et al. PLoS One, 2013. PMID 24069208, Free PMC Article
  5. Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish. Luo J, et al. Brain, 2021 Mar 3. PMID 33279959, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
v-raf-1 murine leukemia viral oncogene homolog 1b
NP_001186684.1
XP_017213720.1
XP_073772006.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199755.1 → NP_001186684.1  RAF proto-oncogene serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001186684.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097130, JBMGRA010000011
    UniProtKB/TrEMBL
    A0A0R4I9V9, A0A8M1NV26, F1QRN2, Q4V900
    Related
    ENSDARP00000076954.6, ENSDART00000082519.8
    Conserved Domains (3) summary
    cd01816
    Location:55 → 129
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    pfam00130
    Location:137 → 185
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:319 → 601
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133186.1 Reference GRCz12tu Primary Assembly

    Range
    524992..577518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073915905.1 → XP_073772006.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A0R4I9V9, A0A8M1NV26, F1QRN2, Q4V900

  2. XM_017358231.4 → XP_017213720.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A0R4I9V9, A0A8M1NV26, F1QRN2, Q4V900
    Conserved Domains (3) summary
    cd01816
    Location:55 → 129
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    pfam00130
    Location:137 → 185
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:319 → 601
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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