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card11 caspase recruitment domain family, member 11 [ Danio rerio (zebrafish) ]

Gene ID: 557072, updated on 9-Sep-2025
Official Symbol
card11provided by ZNC
Official Full Name
caspase recruitment domain family, member 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-100219-1
See related
Ensembl:ENSDARG00000052741 AllianceGenome:ZFIN:ZDB-GENE-100219-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and regulation of immune response. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be active in immunological synapse. Is expressed in gill; intestine; kidney; spleen; and unfertilized egg. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See card11 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (40567241..40644091)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (41558725..41631372)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene si:ch211-222n22.1 Neighboring gene uncharacterized LOC141381257 Neighboring gene guanine nucleotide binding protein (G protein) alpha 12a Neighboring gene eukaryotic translation initiation factor 3, subunit Ba

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Chang MX, et al. Dev Comp Immunol, 2010 Jan. PMID 19699229
  2. Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Liu Y, et al. Environ Sci Technol, 2024 Sep 3. PMID 39141879
  3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in immunological synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
caspase recruitment domain-containing protein 11

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    40567241..40644091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073944926.1 → XP_073801027.1  caspase recruitment domain-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    A0AB32THX8

  2. XM_073944927.1 → XP_073801028.1  caspase recruitment domain-containing protein 11 isoform X2

    UniProtKB/TrEMBL
    A0AB32THX8

  3. XM_073944928.1 → XP_073801029.1  caspase recruitment domain-containing protein 11 isoform X3

    UniProtKB/TrEMBL
    A0AB32THX8

  4. XM_073944929.1 → XP_073801030.1  caspase recruitment domain-containing protein 11 isoform X4

    UniProtKB/TrEMBL
    A0AB32THX8
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials