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IPO9 importin 9 [ Homo sapiens (human) ]

Gene ID: 55705, updated on 27-Nov-2024

Summary

Official Symbol
IPO9provided by HGNC
Official Full Name
importin 9provided by HGNC
Primary source
HGNC:HGNC:19425
See related
Ensembl:ENSG00000198700 MIM:620893; AllianceGenome:HGNC:19425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Imp9
Summary
Enables histone binding activity; histone chaperone activity; and nuclear import signal receptor activity. Involved in proteasome localization and protein import into nucleus. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 7.6), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See IPO9 in Genome Data Viewer
Location:
1q32.1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201829157..201884291)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (201086926..201142038)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201798285..201853419)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neuron navigator 1 Neighboring gene IPO9 antisense RNA 1 Neighboring gene uncharacterized LOC124904483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:201706423-201706974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:201706975-201707524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1694 Neighboring gene RNA, U6 small nuclear 501, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201721153-201721652 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:201757192-201757692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201796884-201797398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201797399-201797912 Neighboring gene Sharpr-MPRA regulatory region 13839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2322 Neighboring gene microRNA 1231 Neighboring gene Sharpr-MPRA regulatory region 12270 Neighboring gene Sharpr-MPRA regulatory region 11581 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:201837758-201837973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201851435-201851934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2323 Neighboring gene Sharpr-MPRA regulatory region 2190 Neighboring gene microRNA 6739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201883337-201883837 Neighboring gene shisa family member 4 Neighboring gene leiomodin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201910579-201911528

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with importin 9 (IPO9) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10402, DKFZp761M1547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone chaperone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteasome localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane HDA PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
importin-9
Names
ran-binding protein 9
ranBP9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018085.5NP_060555.2  importin-9

    See identical proteins and their annotated locations for NP_060555.2

    Status: VALIDATED

    Source sequence(s)
    AF410465, AL513217, AL645504, DA861528, DB232332
    Consensus CDS
    CCDS1415.1
    UniProtKB/Swiss-Prot
    B1ASV5, Q8N1Y1, Q8N3I2, Q8NCG9, Q96P70, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8
    Related
    ENSP00000354742.4, ENST00000361565.9
    Conserved Domains (1) summary
    COG5657
    Location:34812
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    201829157..201884291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    201086926..201142038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)