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RBM22 RNA binding motif protein 22 [ Homo sapiens (human) ]

Gene ID: 55696, updated on 3-May-2020

Summary

Official Symbol
RBM22provided by HGNC
Official Full Name
RNA binding motif protein 22provided by HGNC
Primary source
HGNC:HGNC:25503
See related
Ensembl:ENSG00000086589 MIM:612430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cwc2; ZC3H16; fSAP47
Summary
This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 24.5), lymph node (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See RBM22 in Genome Data Viewer
Location:
5q33.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (150690792..150701089, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150070352..150080669, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene synaptopodin Neighboring gene myozenin 3 Neighboring gene dynactin subunit 4 Neighboring gene small integral membrane protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U6 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
pre-mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-splicing factor RBM22
Names
functional spliceosome-associated protein 47
zinc finger CCCH domain-containing protein 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018047.3NP_060517.1  pre-mRNA-splicing factor RBM22

    See identical proteins and their annotated locations for NP_060517.1

    Status: REVIEWED

    Source sequence(s)
    BC003402, DA534416, N23415
    Consensus CDS
    CCDS34278.1
    UniProtKB/Swiss-Prot
    Q9NW64
    Related
    ENSP00000199814.4, ENST00000199814.9
    Conserved Domains (2) summary
    smart00356
    Location:159185
    ZnF_C3H1; zinc finger
    cd12224
    Location:231304
    RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    150690792..150701089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001742145.2 RNA Sequence

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