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KANSL3 KAT8 regulatory NSL complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 55683, updated on 26-Oct-2022

Summary

Official Symbol
KANSL3provided by HGNC
Official Full Name
KAT8 regulatory NSL complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:25473
See related
Ensembl:ENSG00000114982 MIM:617742; AllianceGenome:HGNC:25473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSL3; Rcd1; KIAA1310
Summary
Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 20.0), ovary (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

See KANSL3 in Genome Data Viewer
Location:
2q11.2
Exon count:
29
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96580494..96638312, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (97099791..97144946, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97258909..97304049, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373496 Neighboring gene AT-rich interaction domain 5A Neighboring gene fer-1 like family member 5 Neighboring gene lectin, mannose binding 2 like

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10081, FLJ23799, KIAA1310

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
KAT8 regulatory NSL complex subunit 3
Names
NSL complex protein NSL3
non-specific lethal 3 homolog
serum inhibited-related protein
testis development protein PRTD

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115016.3NP_001108488.1  KAT8 regulatory NSL complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001108488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC063792, DB275425
    Consensus CDS
    CCDS46361.1
    UniProtKB/Swiss-Prot
    Q9P2N6
    Related
    ENSP00000396749.1, ENST00000431828.6
  2. NM_001349256.2NP_001336185.1  KAT8 regulatory NSL complex subunit 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AC079754, KF456684
  3. NM_001349257.2NP_001336186.1  KAT8 regulatory NSL complex subunit 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC079754
    Consensus CDS
    CCDS92814.1
    UniProtKB/Swiss-Prot
    Q9NWE5
    Related
    ENSP00000499674.1, ENST00000666923.1
  4. NM_001349258.2NP_001336187.1  KAT8 regulatory NSL complex subunit 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC079754
  5. NM_001349259.2NP_001336188.1  KAT8 regulatory NSL complex subunit 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC079754
  6. NM_001349260.2NP_001336189.1  KAT8 regulatory NSL complex subunit 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC079754
    Conserved Domains (1) summary
    cl28330
    Location:66119
    XerC; Integrase [Replication, recombination and repair, Mobilome: prophages, transposons]
  7. NM_001349261.2NP_001336190.1  KAT8 regulatory NSL complex subunit 3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter than isoform 1. Both variants 13 and 14 encode the same isoform (7).
    Source sequence(s)
    AC079754
    Conserved Domains (1) summary
    cl28330
    Location:4497
    XerC; Integrase [Replication, recombination and repair, Mobilome: prophages, transposons]
  8. NM_001349262.2NP_001336191.1  KAT8 regulatory NSL complex subunit 3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter than isoform 1. Both variants 13 and 14 encode the same isoform (7).
    Source sequence(s)
    AC079754
    Conserved Domains (1) summary
    cl28330
    Location:4497
    XerC; Integrase [Replication, recombination and repair, Mobilome: prophages, transposons]

RNA

  1. NR_047653.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AY050169
    Related
    ENST00000354204.10
  2. NR_047654.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, AK023813, DB133508
    Related
    ENST00000447759.5
  3. NR_047655.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, AK302646, BQ063147, DB275425
  4. NR_047656.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, AK304011, DB275425
  5. NR_047657.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, CB123459
    Related
    ENST00000420155.5
  6. NR_047658.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons and contains two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC024276
    Related
    ENST00000487070.5
  7. NR_146098.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  8. NR_146099.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) lacks an alternate exon, contains an alternate exon, and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  9. NR_146100.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) lacks two alternate exons and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  10. NR_146101.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) lacks two alternate exons and contains two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the ztranscript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  11. NR_146102.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) lacks two alternate exons, contains two alternate exons, and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    96580494..96638312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445030.1XP_047300986.1  KAT8 regulatory NSL complex subunit 3 isoform X12

  2. XM_047445024.1XP_047300980.1  KAT8 regulatory NSL complex subunit 3 isoform X11

  3. XM_047444998.1XP_047300954.1  KAT8 regulatory NSL complex subunit 3 isoform X3

  4. XM_047445028.1XP_047300984.1  KAT8 regulatory NSL complex subunit 3 isoform X11

  5. XM_047445033.1XP_047300989.1  KAT8 regulatory NSL complex subunit 3 isoform X16

  6. XM_047445032.1XP_047300988.1  KAT8 regulatory NSL complex subunit 3 isoform X15

  7. XM_047445031.1XP_047300987.1  KAT8 regulatory NSL complex subunit 3 isoform X14

  8. XM_005263987.2XP_005264044.1  KAT8 regulatory NSL complex subunit 3 isoform X10

    See identical proteins and their annotated locations for XP_005264044.1

  9. XM_047445021.1XP_047300977.1  KAT8 regulatory NSL complex subunit 3 isoform X10

  10. XM_047445013.1XP_047300969.1  KAT8 regulatory NSL complex subunit 3 isoform X9

  11. XM_047445015.1XP_047300971.1  KAT8 regulatory NSL complex subunit 3 isoform X9

  12. XM_047445018.1XP_047300974.1  KAT8 regulatory NSL complex subunit 3 isoform X9

  13. XM_047445012.1XP_047300968.1  KAT8 regulatory NSL complex subunit 3 isoform X9

  14. XM_047445048.1XP_047301004.1  KAT8 regulatory NSL complex subunit 3 isoform X23

  15. XM_047445047.1XP_047301003.1  KAT8 regulatory NSL complex subunit 3 isoform X22

  16. XM_011511462.4XP_011509764.1  KAT8 regulatory NSL complex subunit 3 isoform X13

  17. XM_011511459.4XP_011509761.1  KAT8 regulatory NSL complex subunit 3 isoform X4

  18. XM_011511461.4XP_011509763.1  KAT8 regulatory NSL complex subunit 3 isoform X6

  19. XM_047445010.1XP_047300966.1  KAT8 regulatory NSL complex subunit 3 isoform X8

  20. XM_011511460.4XP_011509762.1  KAT8 regulatory NSL complex subunit 3 isoform X5

  21. XM_047445006.1XP_047300962.1  KAT8 regulatory NSL complex subunit 3 isoform X7

  22. XM_011511458.4XP_011509760.1  KAT8 regulatory NSL complex subunit 3 isoform X2

  23. XM_011511454.4XP_011509756.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509756.1

  24. XM_011511455.4XP_011509757.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509757.1

    Conserved Domains (1) summary
    pfam12695
    Location:342436
    Abhydrolase_5; Alpha/beta hydrolase family
  25. XM_047445005.1XP_047300961.1  KAT8 regulatory NSL complex subunit 3 isoform X5

  26. XM_011511456.4XP_011509758.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509758.1

    Conserved Domains (1) summary
    pfam12695
    Location:342436
    Abhydrolase_5; Alpha/beta hydrolase family
  27. XM_047445007.1XP_047300963.1  KAT8 regulatory NSL complex subunit 3 isoform X7

  28. XM_047444996.1XP_047300952.1  KAT8 regulatory NSL complex subunit 3 isoform X1

  29. XM_011511457.4XP_011509759.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509759.1

    Conserved Domains (1) summary
    pfam12695
    Location:342436
    Abhydrolase_5; Alpha/beta hydrolase family
  30. XM_047444995.1XP_047300951.1  KAT8 regulatory NSL complex subunit 3 isoform X1

  31. XM_047445042.1XP_047300998.1  KAT8 regulatory NSL complex subunit 3 isoform X20

  32. XM_047445046.1XP_047301002.1  KAT8 regulatory NSL complex subunit 3 isoform X21

  33. XM_047445034.1XP_047300990.1  KAT8 regulatory NSL complex subunit 3 isoform X17

  34. XM_047445043.1XP_047300999.1  KAT8 regulatory NSL complex subunit 3 isoform X21

  35. XM_047445039.1XP_047300995.1  KAT8 regulatory NSL complex subunit 3 isoform X19

  36. XM_047445035.1XP_047300991.1  KAT8 regulatory NSL complex subunit 3 isoform X18

  37. XM_047445052.1XP_047301008.1  KAT8 regulatory NSL complex subunit 3 isoform X25

  38. XM_047445049.1XP_047301005.1  KAT8 regulatory NSL complex subunit 3 isoform X24

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    97099791..97144946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017991.4: Suppressed sequence

    Description
    NM_017991.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.