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KANSL3 KAT8 regulatory NSL complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 55683, updated on 21-Dec-2019

Summary

Official Symbol
KANSL3provided by HGNC
Official Full Name
KAT8 regulatory NSL complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:25473
See related
Ensembl:ENSG00000114982 MIM:617742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSL3; Rcd1; KIAA1310
Expression
Ubiquitous expression in testis (RPKM 20.0), ovary (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See KANSL3 in Genome Data Viewer
Location:
2q11.2
Exon count:
28
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96593170..96638378, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97258892..97304116, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373496 Neighboring gene AT-rich interaction domain 5A Neighboring gene fer-1 like family member 5 Neighboring gene lectin, mannose binding 2 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10081, FLJ23799, KIAA1310

Gene Ontology Provided by GOA

Process Evidence Code Pubs
histone H4-K16 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
KAT8 regulatory NSL complex subunit 3
Names
NSL complex protein NSL3
non-specific lethal 3 homolog
serum inhibited-related protein
testis development protein PRTD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115016.3NP_001108488.1  KAT8 regulatory NSL complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001108488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC063792, DB275425
    Consensus CDS
    CCDS46361.1
    UniProtKB/Swiss-Prot
    Q9P2N6
    Related
    ENSP00000396749.1, ENST00000431828.6
  2. NM_001349256.2NP_001336185.1  KAT8 regulatory NSL complex subunit 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AC079754, KF456684
  3. NM_001349257.2NP_001336186.1  KAT8 regulatory NSL complex subunit 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC079754
    Related
    ENSP00000499674.1, ENST00000666923.1
  4. NM_001349258.2NP_001336187.1  KAT8 regulatory NSL complex subunit 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC079754
  5. NM_001349259.2NP_001336188.1  KAT8 regulatory NSL complex subunit 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC079754
  6. NM_001349260.2NP_001336189.1  KAT8 regulatory NSL complex subunit 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC079754
    Conserved Domains (1) summary
    cl28330
    Location:66119
    XerC; Integrase [Replication, recombination and repair, Mobilome: prophages, transposons]
  7. NM_001349261.2NP_001336190.1  KAT8 regulatory NSL complex subunit 3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter than isoform 1. Both variants 13 and 14 encode the same isoform (7).
    Source sequence(s)
    AC079754
    Conserved Domains (1) summary
    cl28330
    Location:4497
    XerC; Integrase [Replication, recombination and repair, Mobilome: prophages, transposons]
  8. NM_001349262.2NP_001336191.1  KAT8 regulatory NSL complex subunit 3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, contains an alternate exon in the 3' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter than isoform 1. Both variants 13 and 14 encode the same isoform (7).
    Source sequence(s)
    AC079754
    Conserved Domains (1) summary
    cl28330
    Location:4497
    XerC; Integrase [Replication, recombination and repair, Mobilome: prophages, transposons]

RNA

  1. NR_047653.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AY050169
    Related
    ENST00000354204.10
  2. NR_047654.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, AK023813, DB133508
    Related
    ENST00000447759.5
  3. NR_047655.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, AK302646, BQ063147, DB275425
  4. NR_047656.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, AK304011, DB275425
  5. NR_047657.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA526958, AB037731, CB123459
    Related
    ENST00000420155.5
  6. NR_047658.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons and contains two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC024276
    Related
    ENST00000487070.5
  7. NR_146098.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  8. NR_146099.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) lacks an alternate exon, contains an alternate exon, and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  9. NR_146100.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) lacks two alternate exons and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  10. NR_146101.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) lacks two alternate exons and contains two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the ztranscript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754
  11. NR_146102.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) lacks two alternate exons, contains two alternate exons, and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079754

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96593170..96638378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263987.1XP_005264044.1  KAT8 regulatory NSL complex subunit 3 isoform X6

    See identical proteins and their annotated locations for XP_005264044.1

  2. XM_011511462.3XP_011509764.1  KAT8 regulatory NSL complex subunit 3 isoform X7

  3. XM_011511459.3XP_011509761.1  KAT8 regulatory NSL complex subunit 3 isoform X3

  4. XM_011511461.3XP_011509763.1  KAT8 regulatory NSL complex subunit 3 isoform X5

  5. XM_011511460.3XP_011509762.1  KAT8 regulatory NSL complex subunit 3 isoform X4

  6. XM_011511458.3XP_011509760.1  KAT8 regulatory NSL complex subunit 3 isoform X2

  7. XM_011511454.3XP_011509756.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509756.1

  8. XM_011511467.3XP_011509769.1  KAT8 regulatory NSL complex subunit 3 isoform X11

    Conserved Domains (1) summary
    pfam12695
    Location:136230
    Abhydrolase_5; Alpha/beta hydrolase family
  9. XM_011511466.3XP_011509768.1  KAT8 regulatory NSL complex subunit 3 isoform X10

  10. XM_017004472.2XP_016859961.1  KAT8 regulatory NSL complex subunit 3 isoform X9

  11. XM_011511463.3XP_011509765.1  KAT8 regulatory NSL complex subunit 3 isoform X8

    See identical proteins and their annotated locations for XP_011509765.1

  12. XM_011511455.3XP_011509757.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509757.1

    Conserved Domains (1) summary
    pfam12695
    Location:342436
    Abhydrolase_5; Alpha/beta hydrolase family
  13. XM_011511464.3XP_011509766.1  KAT8 regulatory NSL complex subunit 3 isoform X8

    See identical proteins and their annotated locations for XP_011509766.1

    Conserved Domains (1) summary
    pfam12695
    Location:255349
    Abhydrolase_5; Alpha/beta hydrolase family
  14. XM_011511456.3XP_011509758.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509758.1

    Conserved Domains (1) summary
    pfam12695
    Location:342436
    Abhydrolase_5; Alpha/beta hydrolase family
  15. XM_011511457.3XP_011509759.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011509759.1

    Conserved Domains (1) summary
    pfam12695
    Location:342436
    Abhydrolase_5; Alpha/beta hydrolase family

RNA

  1. XR_427101.1 RNA Sequence

  2. XR_244892.1 RNA Sequence

    Related
    ENST00000670907.1
  3. XR_922963.2 RNA Sequence

  4. XR_001738840.2 RNA Sequence

  5. XR_001738841.2 RNA Sequence

  6. XR_002959316.1 RNA Sequence

    Related
    ENST00000444759.5
  7. XR_001738835.1 RNA Sequence

  8. XR_922962.1 RNA Sequence

  9. XR_002959317.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017991.4: Suppressed sequence

    Description
    NM_017991.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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