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IWS1 interacts with SUPT6H, CTD assembly factor 1 [ Homo sapiens (human) ]

Gene ID: 55677, updated on 23-Nov-2021

Summary

Official Symbol
IWS1provided by HGNC
Official Full Name
interacts with SUPT6H, CTD assembly factor 1provided by HGNC
Primary source
HGNC:HGNC:25467
See related
Ensembl:ENSG00000163166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 10.7), lymph node (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

See IWS1 in Genome Data Viewer
Location:
2q14.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (127480807..127526886, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128238388..128284065, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373608 Neighboring gene microRNA 4783 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa Neighboring gene RNA, U4 small nuclear 48, pseudogene Neighboring gene myosin VIIB Neighboring gene uncharacterized LOC105373609 Neighboring gene uncharacterized LOC101927834

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of IWS1 by shRNA enhances HIV-1 replication in HIV-1-infected CD4+ T-cells and latently infected cells PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, IWS1 PubMed
gag-pol HIV-1 IN displaces IWS1 from PSIP1 (LEDGF/p75) efficiently PubMed
gag-pol The HIV-1 IN interaction site on the PSIP1 (LEDGF/p75) integrase binding domain (IBD) overlaps with that of IWS1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10006, FLJ14655, FLJ32319, MGC126375, MGC126376, DKFZp761G0123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of histone H3-K36 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein IWS1 homolog
Names
IWS1 homolog
IWS1, SUPT6H interacting protein
IWS1-like protein
interacts with Spt6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017969.3NP_060439.2  protein IWS1 homolog

    See identical proteins and their annotated locations for NP_060439.2

    Status: VALIDATED

    Source sequence(s)
    AI638093, BC110537, DA268882
    Consensus CDS
    CCDS2146.1
    UniProtKB/Swiss-Prot
    Q96ST2
    Related
    ENSP00000295321.4, ENST00000295321.9
    Conserved Domains (2) summary
    pfam08618
    Location:228332
    Opi1; Transcription factor Opi1
    cl00146
    Location:528792
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    127480807..127526886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712626.3XP_006712689.1  protein IWS1 homolog isoform X2

    Conserved Domains (2) summary
    pfam08618
    Location:233337
    Opi1; Transcription factor Opi1
    cl00146
    Location:533782
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
  2. XM_017004467.2XP_016859956.1  protein IWS1 homolog isoform X3

  3. XM_005263707.3XP_005263764.1  protein IWS1 homolog isoform X1

    Conserved Domains (2) summary
    pfam08618
    Location:233337
    Opi1; Transcription factor Opi1
    cl00146
    Location:533797
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
  4. XM_017004468.2XP_016859957.1  protein IWS1 homolog isoform X5

    Conserved Domains (2) summary
    pfam08618
    Location:21125
    Opi1; Transcription factor Opi1
    cl00146
    Location:221585
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
  5. XM_011511450.1XP_011509752.1  protein IWS1 homolog isoform X4

    Conserved Domains (2) summary
    pfam08618
    Location:233337
    Opi1; Transcription factor Opi1
    cl00146
    Location:533724
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RNA

  1. XR_001738832.1 RNA Sequence

  2. XR_001738830.1 RNA Sequence

  3. XR_001738831.1 RNA Sequence

  4. XR_001738827.1 RNA Sequence

  5. XR_922960.2 RNA Sequence

  6. XR_001738833.2 RNA Sequence

  7. XR_001738834.2 RNA Sequence

  8. XR_001738829.2 RNA Sequence

  9. XR_001738826.2 RNA Sequence

  10. XR_001738828.1 RNA Sequence

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