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PPP4R3A protein phosphatase 4 regulatory subunit 3A [ Homo sapiens (human) ]

Gene ID: 55671, updated on 5-Jul-2020

Summary

Official Symbol
PPP4R3Aprovided by HGNC
Official Full Name
protein phosphatase 4 regulatory subunit 3Aprovided by HGNC
Primary source
HGNC:HGNC:20219
See related
Ensembl:ENSG00000100796 MIM:610351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
smk1; FLFL1; PP4R3; SMEK1; smk-1; PP4R3A; MSTP033; KIAA2010
Expression
Ubiquitous expression in bone marrow (RPKM 27.7), testis (RPKM 19.4) and 25 other tissues See more
Orthologs

Genomic context

See PPP4R3A in Genome Data Viewer
Location:
14q32.12
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (91457137..91510554, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91923955..91976898, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88C Neighboring gene uncharacterized LOC105370624 Neighboring gene uncharacterized LOC105370625 Neighboring gene COX assembly mitochondrial protein homolog pseudogene Neighboring gene uncharacterized LOC101928957 Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene RNA polymerase III subunit G pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 3A
Names
SMEK homolog 1, suppressor of mek1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284280.1NP_001271209.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1

    See identical proteins and their annotated locations for NP_001271209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB095930, AI608781, BC022778, BC028088
    Consensus CDS
    CCDS9895.1
    UniProtKB/Swiss-Prot
    Q6IN85
    UniProtKB/TrEMBL
    A0A024R6M2, Q8N6W1
    Related
    ENSP00000450864.1, ENST00000554684.5
    Conserved Domains (3) summary
    pfam04802
    Location:166357
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
    cl26969
    Location:325402
    Vitellogenin_N; Lipoprotein amino terminal region
  2. NM_001284281.1NP_001271210.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 3

    See identical proteins and their annotated locations for NP_001271210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 3. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AI608781, BC022778, BC028088, BC038932
    Consensus CDS
    CCDS61532.1
    UniProtKB/Swiss-Prot
    Q6IN85
    UniProtKB/TrEMBL
    Q8N6W1
    Related
    ENSP00000450891.1, ENST00000555462.5
    Conserved Domains (3) summary
    pfam04802
    Location:66118
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:798
    PH-like; Pleckstrin homology-like domain
    cl26969
    Location:86163
    Vitellogenin_N; Lipoprotein amino terminal region
  3. NM_001366432.2NP_001353361.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL133153
    Related
    ENSP00000450883.1, ENST00000554943.5
    Conserved Domains (3) summary
    pfam04802
    Location:166357
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
    cl26969
    Location:325402
    Vitellogenin_N; Lipoprotein amino terminal region

RNA

  1. NR_158976.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133153
  2. NR_169191.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133153
  3. NR_169192.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133153
  4. NR_169193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133153

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    91457137..91510554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267842.2XP_005267899.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

    See identical proteins and their annotated locations for XP_005267899.1

    UniProtKB/Swiss-Prot
    Q6IN85
    Conserved Domains (3) summary
    pfam04802
    Location:166357
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
    cl26969
    Location:325402
    Vitellogenin_N; Lipoprotein amino terminal region

RNA

  1. XR_001750421.2 RNA Sequence

  2. XR_943491.3 RNA Sequence

  3. XR_002957561.1 RNA Sequence

  4. XR_002957560.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017936.3: Suppressed sequence

    Description
    NM_017936.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_032560.4: Suppressed sequence

    Description
    NM_032560.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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