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HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor [ Homo sapiens (human) ]

Gene ID: 55662, updated on 3-Dec-2017
Official Symbol
HIF1ANprovided by HGNC
Official Full Name
hypoxia inducible factor 1 alpha subunit inhibitorprovided by HGNC
Primary source
HGNC:HGNC:17113
See related
Ensembl:ENSG00000166135 MIM:606615; Vega:OTTHUMG00000018911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIH1
Expression
Ubiquitous expression in testis (RPKM 12.2), skin (RPKM 8.6) and 25 other tissues See more
Orthologs
Location:
10q24.31
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (100535884..100553924)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102295641..102313681)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 Neighboring gene paired box 2 Neighboring gene SMC5-SMC6 complex localization factor 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20615, FLJ22027, DKFZp762F1811

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
hypoxia-inducible factor 1-alpha inhibitor
Names
FIH-1
factor inhibiting HIF-1
factor inhibiting HIF1
hypoxia-inducible factor asparagine hydroxylase
peptide-aspartate beta-dioxygenase
NP_060372.2
XP_011538242.1
XP_011538243.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017902.2NP_060372.2  hypoxia-inducible factor 1-alpha inhibitor

    See identical proteins and their annotated locations for NP_060372.2

    Status: VALIDATED

    Source sequence(s)
    AF395830, AL133352, AW015561
    Consensus CDS
    CCDS7498.1
    UniProtKB/Swiss-Prot
    Q9NWT6
    Related
    ENSP00000299163.4, OTTHUMP00000020284, ENST00000299163.6, OTTHUMT00000049865
    Conserved Domains (1) summary
    pfam13621
    Location:53297
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

    Range
    100535884..100553924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539941.1XP_011538243.1  hypoxia-inducible factor 1-alpha inhibitor isoform X2

    Conserved Domains (1) summary
    pfam13621
    Location:3190
    Cupin_8; Cupin-like domain
  2. XM_011539940.2XP_011538242.1  hypoxia-inducible factor 1-alpha inhibitor isoform X1

    Conserved Domains (1) summary
    pfam13621
    Location:80317
    Cupin_8; Cupin-like domain

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    102580289..102598327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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