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RAB20 RAB20, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 55647, updated on 17-Jun-2024

Summary

Official Symbol
RAB20provided by HGNC
Official Full Name
RAB20, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:18260
See related
Ensembl:ENSG00000139832 AllianceGenome:HGNC:18260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activity. Involved in phagosome acidification and phagosome-lysosome fusion. Located in Golgi apparatus and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 17.6), adrenal (RPKM 17.2) and 24 other tissues See more
Orthologs
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Genomic context

See RAB20 in Genome Data Viewer
Location:
13q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (110523066..110561722, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (109753501..109792327, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111175413..111214069, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene collagen type IV alpha 2 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111110079-111110888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111110889-111111697 Neighboring gene COL4A2 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111122078-111122283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111125311-111125885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111127041-111127679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111136580-111137418 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111137419-111138256 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111138257-111139094 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111139095-111139931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111144038-111144573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111144574-111145108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111151293-111151792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111155195-111156124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111159947-111160448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111160449-111160948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111164263-111164891 Neighboring gene COL4A2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111166617-111167116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111170170-111171006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8003 Neighboring gene Sharpr-MPRA regulatory region 8993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111183105-111183721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111186543-111187325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111209741-111210264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111210265-111210787 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111213668-111213857 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:111253624-111254492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111262660-111263160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111263161-111263661 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111266973-111267900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8005 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111284913-111285575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111286570-111287399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111287400-111288228 Neighboring gene NAXD antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111289059-111289887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111301435-111301934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8006 Neighboring gene NAD(P)HX dehydratase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8007 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8011 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111364717-111364885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8012 Neighboring gene inhibitor of growth family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phagosome acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017817.3NP_060287.1  ras-related protein Rab-20

    See identical proteins and their annotated locations for NP_060287.1

    Status: VALIDATED

    Source sequence(s)
    AK000436, BC026025, HY010547
    Consensus CDS
    CCDS9512.1
    UniProtKB/Swiss-Prot
    Q5T9X5, Q9NX49, Q9NX57
    Related
    ENSP00000267328.3, ENST00000267328.5
    Conserved Domains (1) summary
    cd04126
    Location:6233
    Rab20; Rab GTPase family 20 (Rab20)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    110523066..110561722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    109753501..109792327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374729.1XP_054230704.1  ras-related protein Rab-20 isoform X1