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LYAR Ly1 antibody reactive [ Homo sapiens (human) ]

Gene ID: 55646, updated on 3-May-2025
Official Symbol
LYARprovided by HGNC
Official Full Name
Ly1 antibody reactiveprovided by HGNC
Primary source
HGNC:HGNC:26021
See related
Ensembl:ENSG00000145220 MIM:617684; AllianceGenome:HGNC:26021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZLYAR; ZC2HC2
Summary
Enables several functions, including DNA-binding transcription factor binding activity; identical protein binding activity; and transcription regulator inhibitor activity. Involved in several processes, including erythrocyte development; negative regulation of innate immune response; and regulation of DNA-templated transcription. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in testis (RPKM 46.8), lymph node (RPKM 8.5) and 20 other tissues See more
Orthologs
NEW
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See LYAR in Genome Data Viewer
Location:
4p16.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (4267701..4290154, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (4237159..4259618, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (4269428..4291881, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene otopetrin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:4227786-4228406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:4229028-4229648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:4249292-4249918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21227 Neighboring gene transmembrane protein 128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:4258767-4259267 Neighboring gene Sharpr-MPRA regulatory region 9855 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:4271128-4271305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:4289830-4290368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:4290369-4290906 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene uncharacterized LOC112268462

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ20425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
cell growth-regulating nucleolar protein
Names
Ly1 antibody reactive homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145725.2NP_001139197.1  cell growth-regulating nucleolar protein

    See identical proteins and their annotated locations for NP_001139197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL136750, BQ775341
    Consensus CDS
    CCDS3374.1
    UniProtKB/Swiss-Prot
    D3DVS4, Q6FI78, Q9NX58, Q9NYS1
    UniProtKB/TrEMBL
    A8K3Y5
    Related
    ENSP00000397367.1, ENST00000452476.5
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger
  2. NM_017816.3NP_060286.1  cell growth-regulating nucleolar protein

    See identical proteins and their annotated locations for NP_060286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI418609, AK000432, BQ775341
    Consensus CDS
    CCDS3374.1
    UniProtKB/Swiss-Prot
    D3DVS4, Q6FI78, Q9NX58, Q9NYS1
    UniProtKB/TrEMBL
    A8K3Y5
    Related
    ENSP00000345917.4, ENST00000343470.9
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    4267701..4290154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513506.4XP_011511808.1  cell growth-regulating nucleolar protein isoform X1

    See identical proteins and their annotated locations for XP_011511808.1

    UniProtKB/Swiss-Prot
    D3DVS4, Q6FI78, Q9NX58, Q9NYS1
    UniProtKB/TrEMBL
    A8K3Y5
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger
  2. XM_011513505.2XP_011511807.1  cell growth-regulating nucleolar protein isoform X1

    See identical proteins and their annotated locations for XP_011511807.1

    UniProtKB/Swiss-Prot
    D3DVS4, Q6FI78, Q9NX58, Q9NYS1
    UniProtKB/TrEMBL
    A8K3Y5
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    4237159..4259618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350461.1XP_054206436.1  cell growth-regulating nucleolar protein isoform X1

    UniProtKB/Swiss-Prot
    D3DVS4, Q6FI78, Q9NX58, Q9NYS1
    UniProtKB/TrEMBL
    A8K3Y5
  2. XM_054350460.1XP_054206435.1  cell growth-regulating nucleolar protein isoform X1

    UniProtKB/Swiss-Prot
    D3DVS4, Q6FI78, Q9NX58, Q9NYS1
    UniProtKB/TrEMBL
    A8K3Y5