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LYAR Ly1 antibody reactive [ Homo sapiens (human) ]

Gene ID: 55646, updated on 5-Jul-2020

Summary

Official Symbol
LYARprovided by HGNC
Official Full Name
Ly1 antibody reactiveprovided by HGNC
Primary source
HGNC:HGNC:26021
See related
Ensembl:ENSG00000145220 MIM:617684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZLYAR; ZC2HC2
Expression
Broad expression in testis (RPKM 46.8), lymph node (RPKM 8.5) and 20 other tissues See more
Orthologs

Genomic context

See LYAR in Genome Data Viewer
Location:
4p16.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (4267701..4290195, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (4269428..4291896, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 128 Neighboring gene Sharpr-MPRA regulatory region 9855 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene uncharacterized LOC112268462

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cell growth-regulating nucleolar protein
Names
Ly1 antibody reactive homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145725.1NP_001139197.1  cell growth-regulating nucleolar protein

    See identical proteins and their annotated locations for NP_001139197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL136750, BQ775341
    Consensus CDS
    CCDS3374.1
    UniProtKB/Swiss-Prot
    Q9NX58
    Related
    ENSP00000397367.1, ENST00000452476.5
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger
  2. NM_017816.3NP_060286.1  cell growth-regulating nucleolar protein

    See identical proteins and their annotated locations for NP_060286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI418609, AK000432, BQ775341
    Consensus CDS
    CCDS3374.1
    UniProtKB/Swiss-Prot
    Q9NX58
    Related
    ENSP00000345917.4, ENST00000343470.9
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    4267701..4290195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513506.3XP_011511808.1  cell growth-regulating nucleolar protein isoform X1

    See identical proteins and their annotated locations for XP_011511808.1

    UniProtKB/Swiss-Prot
    Q9NX58
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger
  2. XM_011513505.1XP_011511807.1  cell growth-regulating nucleolar protein isoform X1

    See identical proteins and their annotated locations for XP_011511807.1

    UniProtKB/Swiss-Prot
    Q9NX58
    Conserved Domains (1) summary
    pfam08790
    Location:3158
    zf-LYAR; LYAR-type C2HC zinc finger
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