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PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 5564, updated on 1-Jun-2020

Summary

Official Symbol
PRKAB1provided by HGNC
Official Full Name
protein kinase AMP-activated non-catalytic subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:9378
See related
Ensembl:ENSG00000111725 MIM:602740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMPK; HAMPKb
Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 25.5), bone marrow (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See PRKAB1 in Genome Data Viewer
Location:
12q24.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (119667864..119681624)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120105669..120119429)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370027 Neighboring gene transmembrane protein 233 Neighboring gene RN7SK pseudogene 197 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene microRNA 1178 Neighboring gene citron rho-interacting serine/threonine kinase Neighboring gene uncharacterized LOC112268087 Neighboring gene ribosomal protein L35a pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
nail development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit beta-1
Names
5'-AMP-activated protein kinase beta-1 subunit
AMP-activated protein kinase beta subunit
AMPK beta -1 chain
AMPK beta 1
AMPK subunit beta-1
AMPKb
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, noncatalytic, beta-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006253.5NP_006244.2  5'-AMP-activated protein kinase subunit beta-1

    See identical proteins and their annotated locations for NP_006244.2

    Status: REVIEWED

    Source sequence(s)
    AF022116, BC017671, BU539177
    Consensus CDS
    CCDS9191.1
    UniProtKB/Swiss-Prot
    Q9Y478
    UniProtKB/TrEMBL
    A0A024RBN1
    Related
    ENSP00000229328.5, ENST00000229328.10
    Conserved Domains (2) summary
    smart01010
    Location:181270
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:79158
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    119667864..119681624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253909.1XP_005253966.1  5'-AMP-activated protein kinase subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_005253966.1

    UniProtKB/Swiss-Prot
    Q9Y478
    UniProtKB/TrEMBL
    A0A024RBN1
    Related
    ENSP00000441369.1, ENST00000541640.5
    Conserved Domains (2) summary
    smart01010
    Location:181270
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:79158
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
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