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G2E3 G2/M-phase specific E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 55632, updated on 8-Jul-2021

Summary

Official Symbol
G2E3provided by HGNC
Official Full Name
G2/M-phase specific E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:20338
See related
Ensembl:ENSG00000092140 MIM:611299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHF7B; KIAA1333
Expression
Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.4) and 24 other tissues See more
Orthologs
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Genomic context

See G2E3 in Genome Data Viewer
Location:
14q12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (30559136..30620064)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31028364..31089270)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene G2E3 antisense RNA 1 Neighboring gene uncharacterized LOC105370432 Neighboring gene SYF2 pre-mRNA splicing factor pseudogene 1 Neighboring gene sec1 family domain containing 1 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 1 Neighboring gene ribosomal protein L12 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20333, KIAA1333

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G2/M phase-specific E3 ubiquitin-protein ligase
Names
G2/M phase-specific HECT-type E3 ubiquitin transferase
G2/M-phase specific E3 ubiquitin ligase
PHD finger protein 7B
NP_001295026.1
NP_060239.2
XP_011535227.1
XP_011535228.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308097.2NP_001295026.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB037754, AK296872, AW963891, BC008436, BC040179, BM993069
    Consensus CDS
    CCDS76669.1
    UniProtKB/Swiss-Prot
    Q7L622
    UniProtKB/TrEMBL
    B4DL73, F5GX24, Q49AD9
    Related
    ENSP00000391068.2, ENST00000438909.6
    Conserved Domains (4) summary
    smart00119
    Location:365646
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd15496
    Location:186239
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:181
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl00077
    Location:376646
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. NM_017769.5NP_060239.2  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

    See identical proteins and their annotated locations for NP_060239.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB037754, AI432917, BM993069, DA491192
    Consensus CDS
    CCDS9638.1
    UniProtKB/Swiss-Prot
    Q7L622
    Related
    ENSP00000206595.6, ENST00000206595.11
    Conserved Domains (3) summary
    cd15496
    Location:232285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:411692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    30559136..30620064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536926.2XP_011535228.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    Conserved Domains (4) summary
    smart00119
    Location:372653
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl00077
    Location:383653
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl22851
    Location:210246
    PHD_SF; PHD finger superfamily
  2. XM_011536925.2XP_011535227.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

    See identical proteins and their annotated locations for XP_011535227.1

    UniProtKB/Swiss-Prot
    Q7L622
    Related
    ENSP00000451653.1, ENST00000553504.5
    Conserved Domains (3) summary
    cd15496
    Location:232285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:411692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. XR_001750412.2 RNA Sequence

  2. XR_001750411.2 RNA Sequence

  3. XR_001750409.2 RNA Sequence

  4. XR_001750413.2 RNA Sequence

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