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ZNF407 zinc finger protein 407 [ Homo sapiens (human) ]

Gene ID: 55628, updated on 10-Oct-2019

Summary

Official Symbol
ZNF407provided by HGNC
Official Full Name
zinc finger protein 407provided by HGNC
Primary source
HGNC:HGNC:19904
See related
Ensembl:ENSG00000215421 MIM:615894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in testis (RPKM 1.7), ovary (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF407 in Genome Data Viewer
Location:
18q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (74590475..75065672)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72265106..72777628)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene carnosine dipeptidase 2 Neighboring gene carnosine dipeptidase 1 Neighboring gene long intergenic non-protein coding RNA 909 Neighboring gene VISTA enhancer hs378 Neighboring gene VISTA enhancer hs824 Neighboring gene uncharacterized LOC107985130 Neighboring gene uncharacterized LOC105376874 Neighboring gene zinc binding alcohol dehydrogenase domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-11)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-11)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
NHGRI GWA Catalog
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13839, FLJ20307, KIAA1703

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013216.1 RefSeqGene

    Range
    5001..439710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146189.1NP_001139661.1  zinc finger protein 407 isoform 2

    See identical proteins and their annotated locations for NP_001139661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing the 3' terminal exon, and contains an alternate segment at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB051490, AC138660, AK000314, AK056288, DB096147
    Consensus CDS
    CCDS58634.1
    UniProtKB/Swiss-Prot
    Q9C0G0
    Related
    ENSP00000463270.1, ENST00000577538.5
    Conserved Domains (3) summary
    sd00017
    Location:16301650
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:16421669
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001146190.1NP_001139662.1  zinc finger protein 407 isoform 3

    See identical proteins and their annotated locations for NP_001139662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing several exons from the 3' end, and contains an alternate exon at the 3' end compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB051490, AC138660, AK000314, AK000317, AK056288, DB096147
    Consensus CDS
    CCDS54191.1
    UniProtKB/Swiss-Prot
    Q9C0G0
    Related
    ENSP00000310359.5, ENST00000309902.10
    Conserved Domains (3) summary
    sd00017
    Location:15391561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:15571578
    zf-H2C2_2; Zinc-finger double domain
  3. NM_017757.2NP_060227.2  zinc finger protein 407 isoform 1

    See identical proteins and their annotated locations for NP_060227.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB051490, AC015819, AC138660
    Consensus CDS
    CCDS45885.1
    UniProtKB/Swiss-Prot
    Q9C0G0
    Related
    ENSP00000299687.4, ENST00000299687.9
    Conserved Domains (4) summary
    COG5048
    Location:17121767
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:16301650
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:16421669
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    74590475..75065672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266726.5XP_005266783.1  zinc finger protein 407 isoform X1

    See identical proteins and their annotated locations for XP_005266783.1

    UniProtKB/Swiss-Prot
    Q9C0G0
    Conserved Domains (4) summary
    COG5048
    Location:17121767
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:16301650
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:16421669
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017025838.2XP_016881327.1  zinc finger protein 407 isoform X2

  3. XM_011526069.3XP_011524371.1  zinc finger protein 407 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:15391561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:15571578
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011526070.2XP_011524372.1  zinc finger protein 407 isoform X4

    See identical proteins and their annotated locations for XP_011524372.1

    UniProtKB/Swiss-Prot
    Q9C0G0
    Related
    ENSP00000462348.1, ENST00000582337.5
    Conserved Domains (3) summary
    sd00017
    Location:15391561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:15571578
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006722500.4XP_006722563.1  zinc finger protein 407 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:15391561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:15571578
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011526068.2XP_011524370.1  zinc finger protein 407 isoform X1

    See identical proteins and their annotated locations for XP_011524370.1

    UniProtKB/Swiss-Prot
    Q9C0G0
    Conserved Domains (4) summary
    COG5048
    Location:17121767
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:16301650
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14161445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:16421669
    zf-H2C2_2; Zinc-finger double domain
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