cblb Cbl proto-oncogene B, E3 ubiquitin protein ligase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cblbprovided by ZNC
Official Full Name: Cbl proto-oncogene B, E3 ubiquitin protein ligaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-417
See related: Ensembl:ENSDARG00000015199 AllianceGenome:ZFIN:ZDB-GENE-030616-417
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CBL; Cas-Br-M; dZ25N23.1; si:dz25n23.1; si:dz39l02.2; si:busm1-25n23.1; si:busm1-39l02.2
Summary: Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor receptor signaling pathway and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	10	NC_133185.1 (33508074..33654952)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (28587501..28731667)

Chromosome 10 - NC_133185.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of signaling	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info