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TTC27 tetratricopeptide repeat domain 27 [ Homo sapiens (human) ]

Gene ID: 55622, updated on 1-Jun-2020

Summary

Official Symbol
TTC27provided by HGNC
Official Full Name
tetratricopeptide repeat domain 27provided by HGNC
Primary source
HGNC:HGNC:25986
See related
Ensembl:ENSG00000018699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 8.0), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See TTC27 in Genome Data Viewer
Location:
2p22.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (32628035..32821051)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32853087..33046118)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat containing 6 Neighboring gene BIRC6 antisense RNA 2 Neighboring gene microRNA 558 Neighboring gene microRNA 4765 Neighboring gene Sharpr-MPRA regulatory region 6729 Neighboring gene long intergenic non-protein coding RNA 486 Neighboring gene uncharacterized LOC105374453 Neighboring gene latent transforming growth factor beta binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20272

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 27
Names
TPR repeat protein 27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193509.2NP_001180438.1  tetratricopeptide repeat protein 27 isoform 2

    See identical proteins and their annotated locations for NP_001180438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in its first exon, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL121656, AL133246
    UniProtKB/Swiss-Prot
    Q6P3X3
    UniProtKB/TrEMBL
    B4DRC7
    Conserved Domains (3) summary
    sd00006
    Location:477505
    TPR; TPR repeat [structural motif]
    pfam07719
    Location:513544
    TPR_2; Tetratricopeptide repeat
    pfam13414
    Location:513575
    TPR_11; TPR repeat
  2. NM_017735.5NP_060205.3  tetratricopeptide repeat protein 27 isoform 1

    See identical proteins and their annotated locations for NP_060205.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AL121656, AL133246
    Consensus CDS
    CCDS33176.1
    UniProtKB/Swiss-Prot
    Q6P3X3
    Related
    ENSP00000313953.4, ENST00000317907.9
    Conserved Domains (2) summary
    COG0457
    Location:475631
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:527555
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    32628035..32821051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532958.2XP_011531260.1  tetratricopeptide repeat protein 27 isoform X1

    Conserved Domains (2) summary
    sd00006
    Location:527555
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:526592
    TPR_11; TPR repeat
  2. XM_005264416.2XP_005264473.1  tetratricopeptide repeat protein 27 isoform X2

    Conserved Domains (3) summary
    sd00006
    Location:486514
    TPR; TPR repeat [structural motif]
    pfam07719
    Location:522553
    TPR_2; Tetratricopeptide repeat
    pfam13414
    Location:522584
    TPR_11; TPR repeat

RNA

  1. XR_002959314.1 RNA Sequence

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