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TRMT1 tRNA methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 55621, updated on 9-Feb-2020

Summary

Official Symbol
TRMT1provided by HGNC
Official Full Name
tRNA methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:25980
See related
Ensembl:ENSG00000104907 MIM:611669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM1; MRT68
Summary
This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in spleen (RPKM 12.4), lymph node (RPKM 11.5) and 25 other tissues See more
Orthologs

Genomic context

See TRMT1 in Genome Data Viewer
Location:
19p13.13
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (13104900..13117567, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13215714..13227573, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene nuclear factor I X Neighboring gene uncharacterized LOC105372282 Neighboring gene Sharpr-MPRA regulatory region 14065 Neighboring gene LYL1 basic helix-loop-helix family member Neighboring gene nucleus accumbens associated 1 Neighboring gene syntaxin 10 Neighboring gene immediate early response 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA (guanine-N2-)-methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
tRNA (guanine-N2-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
tRNA N2-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA modification TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tRNA (guanine(26)-N(2))-dimethyltransferase
Names
N(2),N(2)-dimethylguanosine tRNA methyltransferase
TRM1 tRNA methyltransferase 1 homolog
tRNA 2,2-dimethylguanosine-26 methyltransferase
tRNA methyltransferase 1 homolog
tRNA(guanine-26,N(2)-N(2)) methyltransferase
tRNA(m(2,2)G26)dimethyltransferase
NP_001129507.1
NP_001136026.1
NP_001338689.1
NP_001338690.1
NP_001338691.1
NP_060192.1
XP_024307355.1
XP_024307356.1
XP_024307357.1
XP_024307358.1
XP_024307359.1
XP_024307360.1
XP_024307361.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054900.1 RefSeqGene

    Range
    5797..17668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136035.4NP_001129507.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001129507.1

    Status: REVIEWED

    Source sequence(s)
    AC005546
    Consensus CDS
    CCDS12293.1
    UniProtKB/Swiss-Prot
    Q9NXH9
    UniProtKB/TrEMBL
    A0A024R7I5
    Related
    ENSP00000350352.4, ENST00000357720.8
    Conserved Domains (3) summary
    smart00356
    Location:600626
    ZnF_C3H1; zinc finger
    pfam02005
    Location:45500
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    cl25637
    Location:571624
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  2. NM_001142554.3NP_001136026.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001136026.1

    Status: REVIEWED

    Source sequence(s)
    AC005546, BC018302, DC313999
    Consensus CDS
    CCDS45997.1
    UniProtKB/Swiss-Prot
    Q9NXH9
    Related
    ENSP00000221504.7, ENST00000221504.12
    Conserved Domains (3) summary
    smart00356
    Location:571597
    ZnF_C3H1; zinc finger
    pfam02005
    Location:45471
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    cl25637
    Location:542595
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  3. NM_001351760.2NP_001338689.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK000251, BQ212049, DC365548
    Consensus CDS
    CCDS45997.1
    Conserved Domains (3) summary
    smart00356
    Location:571597
    ZnF_C3H1; zinc finger
    pfam02005
    Location:45471
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    cl25637
    Location:542595
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  4. NM_001351761.2NP_001338690.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK000251, DC373552
    Conserved Domains (3) summary
    smart00356
    Location:564590
    ZnF_C3H1; zinc finger
    pfam02005
    Location:9464
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    cl25637
    Location:535588
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  5. NM_001351762.2NP_001338691.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK000251, DA202329
    Conserved Domains (3) summary
    smart00356
    Location:339365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:310363
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  6. NM_017722.4NP_060192.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

    See identical proteins and their annotated locations for NP_060192.1

    Status: REVIEWED

    Source sequence(s)
    BC040126, BF798026, DC313999
    Consensus CDS
    CCDS12293.1
    UniProtKB/Swiss-Prot
    Q9NXH9
    UniProtKB/TrEMBL
    A0A024R7I5
    Related
    ENSP00000416149.1, ENST00000437766.5
    Conserved Domains (3) summary
    smart00356
    Location:600626
    ZnF_C3H1; zinc finger
    pfam02005
    Location:45500
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    cl25637
    Location:571624
    DFRP_C; DRG Family Regulatory Proteins, Tma46

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    13104900..13117567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451592.1XP_024307360.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (3) summary
    smart00356
    Location:339365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:310363
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  2. XM_024451588.1XP_024307356.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

    Conserved Domains (3) summary
    smart00356
    Location:386412
    ZnF_C3H1; zinc finger
    cl17173
    Location:1286
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:357410
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  3. XM_024451593.1XP_024307361.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (3) summary
    smart00356
    Location:339365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:310363
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  4. XM_024451590.1XP_024307358.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

    Conserved Domains (3) summary
    smart00356
    Location:357383
    ZnF_C3H1; zinc finger
    cl17173
    Location:1257
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:328381
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  5. XM_024451589.1XP_024307357.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

    Conserved Domains (3) summary
    smart00356
    Location:386412
    ZnF_C3H1; zinc finger
    cl17173
    Location:1286
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:357410
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  6. XM_024451591.1XP_024307359.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

    Conserved Domains (3) summary
    smart00356
    Location:339365
    ZnF_C3H1; zinc finger
    cl17173
    Location:1239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:310363
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  7. XM_024451587.1XP_024307355.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

    Conserved Domains (3) summary
    smart00356
    Location:386412
    ZnF_C3H1; zinc finger
    cl17173
    Location:1286
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl25637
    Location:357410
    DFRP_C; DRG Family Regulatory Proteins, Tma46

RNA

  1. XR_002958328.1 RNA Sequence

    Related
    ENST00000593157.5
  2. XR_002958329.1 RNA Sequence

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