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DOCK10 dedicator of cytokinesis 10 [ Homo sapiens (human) ]

Gene ID: 55619, updated on 5-Aug-2018

Summary

Official Symbol
DOCK10provided by HGNC
Official Full Name
dedicator of cytokinesis 10provided by HGNC
Primary source
HGNC:HGNC:23479
See related
Ensembl:ENSG00000135905 MIM:611518; Vega:OTTHUMG00000153428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIZ3; DRIP2; Nbla10300
Summary
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
Expression
Broad expression in spleen (RPKM 10.3), lymph node (RPKM 9.4) and 22 other tissues See more
Orthologs

Genomic context

See DOCK10 in Genome Data Viewer
Location:
2q36.2
Exon count:
58
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (224765090..225042689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (225629807..225907330, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373910 Neighboring gene uncharacterized LOC105373911 Neighboring gene microRNA 4439 Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Neighboring gene uncharacterized LOC105373914 Neighboring gene uncharacterized LOC107985992

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dedicator of cytokinesis 10 (DOCK10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781A1532

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
marginal zone B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dedicator of cytokinesis protein 10
Names
dopamine receptor interacting protein 2
zizimin3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034039.1 RefSeqGene

    Range
    5001..282524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290263.1NP_001277192.1  dedicator of cytokinesis protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001277192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2; also known as DOCK10.2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a distinct start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC011739, DB128847, EU236710
    Consensus CDS
    CCDS74661.1
    UniProtKB/Swiss-Prot
    Q96BY6
    Related
    ENSP00000386694.3, OTTHUMP00000203874, ENST00000409592.7, OTTHUMT00000331158
    Conserved Domains (5) summary
    cd08697
    Location:665854
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:16902135
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:176296
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:176283
    PH; PH domain
    pfam11878
    Location:60147
    DUF3398; Domain of unknown function (DUF3398)
  2. NM_001363762.1NP_001350691.1  dedicator of cytokinesis protein 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a distinct start codon, compared to variant 1. The resulting protein (isoform 3) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC011739, AC093806
    Consensus CDS
    CCDS86925.1
    Conserved Domains (4) summary
    cd08697
    Location:684873
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:17092154
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:195315
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:79166
    DUF3398; Domain of unknown function (DUF3398)
  3. NM_014689.2NP_055504.2  dedicator of cytokinesis protein 10 isoform 1

    See identical proteins and their annotated locations for NP_055504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1; also known as DOCK10.1) encodes isoform 1.
    Source sequence(s)
    AB014594, AC011739, AC017095, CR749492, DN991477, EG328193, EG328223, EG328495, EG328518, EG328531, EG328562
    Consensus CDS
    CCDS46528.1
    UniProtKB/Swiss-Prot
    Q96BY6
    Related
    ENSP00000258390.7, OTTHUMP00000203922, ENST00000258390.11, OTTHUMT00000331246
    Conserved Domains (5) summary
    cd08697
    Location:671860
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:16962141
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:182302
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:182289
    PH; PH domain
    pfam11878
    Location:66153
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    224765090..225042689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004447.1XP_016859936.1  dedicator of cytokinesis protein 10 isoform X9

  2. XM_006712617.4XP_006712680.1  dedicator of cytokinesis protein 10 isoform X6

    Conserved Domains (5) summary
    cd08697
    Location:684873
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:17092154
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:195315
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:195302
    PH; PH domain
    pfam11878
    Location:79166
    DUF3398; Domain of unknown function (DUF3398)
  3. XM_005246673.4XP_005246730.1  dedicator of cytokinesis protein 10 isoform X7

    Related
    ENSP00000493664.1, ENST00000645028.1
    Conserved Domains (4) summary
    cd08697
    Location:684873
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:17092154
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:195315
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:79166
    DUF3398; Domain of unknown function (DUF3398)
  4. XM_017004443.2XP_016859932.1  dedicator of cytokinesis protein 10 isoform X3

  5. XM_017004446.2XP_016859935.1  dedicator of cytokinesis protein 10 isoform X8

  6. XM_017004442.2XP_016859931.1  dedicator of cytokinesis protein 10 isoform X2

  7. XM_017004444.2XP_016859933.1  dedicator of cytokinesis protein 10 isoform X4

  8. XM_017004441.2XP_016859930.1  dedicator of cytokinesis protein 10 isoform X1

  9. XM_017004445.2XP_016859934.1  dedicator of cytokinesis protein 10 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017718.1: Suppressed sequence

    Description
    NM_017718.1: This RefSeq was permanently suppressed because it is a a nonsense-mediated mRNA decay (NMD) candidate.
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