slc1a3b solute carrier family 1 member 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc1a3bprovided by ZNC
Official Full Name: solute carrier family 1 member 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090708-3
See related: Ensembl:ENSDARG00000043148 AllianceGenome:ZFIN:ZDB-GENE-090708-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-21n12.2
Summary: Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in D-aspartate import across plasma membrane; L-aspartate import across plasma membrane; and L-glutamate import across plasma membrane. Predicted to act upstream of or within amino acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	10	NC_133185.1 (41612220..41643164, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (36554985..36592486, complement)

Chromosome 10 - NC_133185.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-aspartate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 1 member 3b

Names: EAAT1B; excitatory amino acid transporter SLC1A3b; glastb; solute carrier family 1 (glial high affinity glutamate transporter), member 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.